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Meiotic recombination is vital for maintaining the sequence diversity in human genome. Meiosis and recombination are considered the essential phases of cell division. In meiosis, the genome is divided into equal parts for sexual reproduction whereas in recombination, the diverse genomes are combined to form new combination of genetic variations. The region of chromosomes where the frequency of recombination is high is called hotspot and the region where the frequency is low recombination is referred to as coldspot. The identification of recombination spots is very essential to understand the reproduction and growth of the cells.
(Kabir et al., 2016) iRSpot-GAEnsC: identifing recombination spots via ensemble classifier and extending the concept of Chou's PseAAC to formulate DNA samples. Molecular Genetics and Genomics.