DomIns specifications


Unique identifier OMICS_04520
Name DomIns
Restrictions to use None
Database management system MySQL
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • person_outline Aroul Selvam Ramadass
  • person_outline Ramkumar Hariharan

Publication for DomIns

DomIns citation


Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin*

PMCID: 2937989
PMID: 20610383
DOI: 10.1074/jbc.M109.095455

[…] composed of nonsequential helices, i.e. helix α1, α2, α3, α8, and α9 (equivalent to helices 28, 29, 30, 35, and 36 of the talin rod). Such an insertion has not previously been identified as judged by DomIns.There is no interaction between the two bundles in the crystal structure, and none of the contacts in the crystal lattice seem biologically relevant. The topology of the helices and nature of t […]

DomIns institution(s)
The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, UK; MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK
DomIns funding source(s)
Supported by Cambridge Commonwealth Trust and the Medical Research Council, UK.

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