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DOMMINO specifications


Unique identifier OMICS_02883
Restrictions to use None
Maintained Yes

Publication for DOMMINO

DOMMINO citations


Incorporation of protein binding effects into likelihood ratio test for exome sequencing data

BMC Proc
PMCID: 5133515
PMID: 27980649
DOI: 10.1186/s12919-016-0043-8

[…] ence-based and structure-based methods have been assessed using 10-fold cross-validation on a set of 335 protein sequences with their binding sites extracted from hetero-oligomeric complexes from the DOMMINO (Database of Macromolecular Interactions) database []. We then select a classifier with the highest f-measure value defined by, where Pr and Re are the precision and recall values, respectivel […]


Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Nat Commun
PMCID: 3996537
PMID: 24722188
DOI: 10.1038/ncomms4650

[…] To identify protein pairs with solved or modelled structures, for each protein pair, the structural templates covering the interactions between domains of each protein were derived using SUPERFAMILY, DOMMINO or PSI-BLAST. Once the templates were obtained, the coverage of each template was further expanded by using templates from the PDB ( A homology model of the interaction w […]


Extreme Evolutionary Conservation of Functionally Important Regions in H1N1 Influenza Proteome

PLoS One
PMCID: 3839886
PMID: 24282564
DOI: 10.1371/journal.pone.0081027

[…] significant region was functionally annotated. Specifically, we mapped intra- and inter-species binding sites of the H1N1 influenza proteins collected from our database of macromolecular interactions DOMMINO [] and PubMed literature search, and then determined if each of the conserved regions overlap with any of the mapped binding sites (see ). […]


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DOMMINO institution(s)
Informatics Institute and Department of Computer Science and Bond Life Science Center, University of Missouri, Columbia, MO, USA

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