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Publication for DOMMINO
Incorporation of protein binding effects into likelihood ratio test for exome sequencing data
[…] ence-based and structure-based methods have been assessed using 10-fold cross-validation on a set of 335 protein sequences with their binding sites extracted from hetero-oligomeric complexes from the DOMMINO (Database of Macromolecular Interactions) database . We then select a classifier with the highest f-measure value defined by, where Pr and Re are the precision and recall values, respectivel […]
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism
[…] To identify protein pairs with solved or modelled structures, for each protein pair, the structural templates covering the interactions between domains of each protein were derived using SUPERFAMILY, DOMMINO or PSI-BLAST. Once the templates were obtained, the coverage of each template was further expanded by using templates from the PDB ( http://www.pdb.org/). A homology model of the interaction w […]
Extreme Evolutionary Conservation of Functionally Important Regions in H1N1 Influenza Proteome
[…] significant region was functionally annotated. Specifically, we mapped intra- and inter-species binding sites of the H1N1 influenza proteins collected from our database of macromolecular interactions DOMMINO  and PubMed literature search, and then determined if each of the conserved regions overlap with any of the mapped binding sites (see ). […]
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