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Dr Fit specifications

Information


Unique identifier OMICS_13910
Name Dr Fit
Alternative name Dose-Response FITting
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Input data Several replicates and various concentration points
Input format XLS
Output data Graph
Output format PNG
Operating system Windows
License MIT License
Computer skills Medium
Version 1.042
Stability Stable
Requirements
MATLAB
Maintained Yes

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Publication for Dose-Response FITting

Dr Fit citations

 (18)
library_books

Synergistic antifungal effect of chitosan stabilized selenium nanoparticles synthesized by pulsed laser ablation in liquids against Candida albicans biofilms

2018
PMCID: 5937483
PMID: 29760550
DOI: 10.2147/IJN.S151285

[…] The IC50 was calculated by dose–response fitting using Origin 9 software. The graphs show the mean ± standard error of the mean from three separate experiments performed in duplicate. For quantitative assays, statistical analys […]

library_books

Neonicotinoids act like endocrine disrupting chemicals in newly emerged bees and winter bees

2017
Sci Rep
PMCID: 5591280
PMID: 28887455
DOI: 10.1038/s41598-017-10489-6

[…] For acute toxicity studies, the LD50 values were calculated using the Dr. Fit program (within R stats program) that uses a modified model and automated fitting procedure to describe dose-response curves with monotonic and multiphasic features. The resulting general mode […]

library_books

Synthesis and biochemical characterization of EGF receptor in a water soluble membrane model system

2017
PLoS One
PMCID: 5460842
PMID: 28586369
DOI: 10.1371/journal.pone.0177761

[…] f NLPs to the sensors. Plots of association responses (nm) from 1990–1995 s were created against log concentration [M] of empty or EGFR-NLPs and EC50 and Hill Slopes were calculated using a sigmoidal dose response fitting with variable slope in GraphPad Prism. To determine the inhibition of EGFR-NLP to EGF binding, 100 nM EGFR-NLPs were incubated with 1 μM unlabeled EGF or a 1.5-fold titration ser […]

call_split

Discovery of a small molecule targeting ULK1 modulated cell death of triple negative breast cancer in vitro and in vivo † †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05368h Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file. Click here for additional data file.

2017
PMCID: 5433508
PMID: 28553505
DOI: 10.1039/c6sc05368h
call_split See protocol

[…] L of kinase detection reagent was added. After incubation at room temperature for 30 minutes, the luminescence was recorded. The EC50 values were calculated using nonlinear regression with normalized dose–response fitting using Prism software (GraphPad Software, San Diego, CA, USA). To exclude the possibility that the increased kinase activity might be due to aggregation, 0.02% Triton-X was used a […]

library_books

The effects of arginine glutamate, a promising excipient for protein formulation, on cell viability: Comparisons with NaCl

2016
PMCID: 4837223
PMID: 26873863
DOI: 10.1016/j.tiv.2016.02.002

[…] o software (Tree Star Inc., Ashland, OR, USA). Dose response curves were obtained and IC50 values (the concentration/osmolality required to cause a 50% loss in viability) calculated using the inbuilt dose–response fitting function with a nonlinear fit analysis in the OriginPro software version 9.0. […]

library_books

Activation of the Nrf2 ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II

2016
PMCID: 5225202
PMID: 27178040
DOI: 10.1007/s00204-016-1726-7

[…] of 24 h and WST-1 dye was added in serum-free medium. After 45 min the absorption at 450 nm was measured, values were normalized to respective control. The EC50 was calculated with OriginPro 9.1 with dose–response fitting. […]

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Dr Fit institution(s)
CRUK Cambridge Institute, University of Cambridge, Cambridge, UK; NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MA, USA
Dr Fit funding source(s)
This work was funded by Cancer Research UK grant C14303/A17197.

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