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Dr Fit specifications

Information


Unique identifier OMICS_13910
Name Dr Fit
Alternative name Dose-Response FITting
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Input data Several replicates and various concentration points
Input format XLS
Output data Graph
Output format PNG
Operating system Windows
License MIT License
Computer skills Medium
Version 1.042
Stability Stable
Requirements
MATLAB
Maintained Yes

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Publication for Dose-Response FITting

Dr Fit citations

 (7)
library_books

Synthesis and biochemical characterization of EGF receptor in a water soluble membrane model system

2017
PMCID: 5460842
PMID: 28586369
DOI: 10.1371/journal.pone.0177761

[…] nlps to the sensors. plots of association responses (nm) from 1990–1995 s were created against log concentration [m] of empty or egfr-nlps and ec50 and hill slopes were calculated using a sigmoidal dose response fitting with variable slope in graphpad prism. to determine the inhibition of egfr-nlp to egf binding, 100 nm egfr-nlps were incubated with 1 μm unlabeled egf or a 1.5-fold titration […]

library_books

Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin

2015
PMCID: 4631386
PMID: 26529318
DOI: 10.1371/journal.pone.0141692

[…] all experiments were conducted in triplicate. kd and ic50 values were obtained through data fitting performed in kaleidagraph using a four-parameter logistic model, according to the sigmoidal dose-response fitting function: y=m1+(m2-m1)1+(xm3)m4(1) where m1 and m2 are the fluorescence intensity values at zero and maximum analyte concentrations, respectively, x is the analyte […]

library_books

Cell cycle association and hypoxia regulation of excision repair cross complementation group 1 protein (ERCC1) in tumor cells of head and neck cancer

2014
PMCID: 4158184
PMID: 24817012
DOI: 10.1007/s13277-014-2001-2

[…] the treated cells were related to the controls as percentage of growth capacity. the relationship between growth capacity and treatment drug concentrations was analyzed by regression using nonlinear dose-response fitting methods of graphpad prism 4.03 (graphpad software inc, san diego, ca, usa), and concentrations were determined, which cause 50 % growth inhibition compared to untreated cells […]

library_books

In This Issue of Diabetes Care

2013
PMCID: 3781500
DOI: 10.2337/dc13-ti10

[…] cross-sectional association between severity of dr and cognitive impairment. while only 5% of the pdr group had results indicating severe cognitive impairment or dementia, 12% of those with no/mild dr fit this description. the authors point out that a number of factors should be considered when interpreting their results. these include the possibility that residual confounding associated […]

library_books

Rapid on site/in situ detection of heavy metal ions in environmental water using a structure switching DNA optical biosensor

2013
PMCID: 3725506
PMID: 23892693
DOI: 10.1038/srep02308

[…] with the dose-response curve and the s/n ratio of 5.1, the detection limit was determined as approximately 1.2 nm based on the average standard deviation of the measurements (σ) and the slope of the dose-response fitting curve (s) as 3σ/s. therefore, this novel sensor can be applied to the direct detection of hg2+ in natural water with the ability to meet even the most stringent requirements […]

library_books

Inhibition of poly(ADP ribose) Polymerase Interferes with Trypanosoma cruzi Infection and Proliferation of the Parasite

2012
PMCID: 3457943
PMID: 23049934
DOI: 10.1371/journal.pone.0046063

[…] but the incubation time was set so that the substrate conversion in the control wells was approximately 20%. the fluorescence signal was converted to inhibition percentage and fitted using sigmoidal dose-response fitting with variable slope (graphpad prism). the curves were extrapolated to 0% and 100% of inhibition by setting their inhibitor concentration 2 log units below or above the first […]


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Dr Fit institution(s)
CRUK Cambridge Institute, University of Cambridge, Cambridge, UK; NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MA, USA
Dr Fit funding source(s)
This work was funded by Cancer Research UK grant C14303/A17197.

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