drexplorer specifications

Information


Unique identifier OMICS_07251
Name drexplorer
Software type Package/Module
Interface Command line interface, Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes

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Publication for drexplorer

drexplorer in publications

 (4)
PMCID: 5865668
PMID: 29581842
DOI: 10.18632/oncotarget.24361

[…] cell lines with the wilcoxon rank sum test. we selected agents for this comparison that targeted proteins found to have increased expression on rppa. the chou-talalay method implemented by the drexplorer software was used to estimate the interaction index (iai) to assess the degree of drug interactions for combination treatments. iai values less than 1 indicate a trend towards synergism […]

PMCID: 5683351
PMID: 28892078
DOI: 10.1038/nbt.3955

[…] or were generously given by the laboratory of dr. nathanael gray (harvard medical school). an estimator of the response to drugs (auc: area under the dose response curve) was obtained using drexplorer 1.1.0 in r (r3.1.0)., gene ontology (go) category analysis of proteins with dysregulated protein-protein associations enriched in cells of either basal or luminal subtype were done […]

PMCID: 5216995
PMID: 27384992
DOI: 10.18632/oncotarget.10332

[…] at least two biological replicates were tested on different days. ic50 and ic70 values were estimated from the best-fit dose-response model selected by residual standard error using the r package drexplorer []., cells were lysed in cell lysis buffer, and the cell lysates' protein concentrations were measured with the bca protein assay kit (pierce biotechnology, rockford, il) as previously […]

PMCID: 4824499
PMID: 27055253
DOI: 10.1371/journal.pone.0152584

[…] control. four days later, proliferation was assayed by cell titer glo (promega, fitchburg, wi). for single-drug treatments, median inhibitory concentration (ic50) values were estimated by the drexplorer software []. specifically, for each drug combination (at each dose level), the observed (or experimental) effect of the combination was compared to the predicted additive effect. data […]


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drexplorer institution(s)
Departments of Bioinformatics and Computational Biology, Houston, TX, USA; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA; Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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