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Protocols

drexplorer specifications

Information


Unique identifier OMICS_07251
Name drexplorer
Software type Package/Module
Interface Command line interface, Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes

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Publication for drexplorer

drexplorer citations

 (4)
library_books

Integrative proteomic and transcriptomic analysis provides evidence for TrkB (NTRK2) as a therapeutic target in combination with tyrosine kinase inhibitors for non small cell lung cancer

2018
Oncotarget
PMCID: 5865668
PMID: 29581842
DOI: 10.18632/oncotarget.24361

[…] on-SCC cell lines with the Wilcoxon rank sum test. We selected agents for this comparison that targeted proteins found to have increased expression on RPPA. The Chou-Talalay method implemented by the drexplorer software was used to estimate the interaction index (IAI) to assess the degree of drug interactions for combination treatments. IAI values less than 1 indicate a trend towards synergism and […]

call_split

Detection of Dysregulated Protein Association Networks by High Throughput Proteomics Predicts Cancer Vulnerabilities

2017
Nat Biotechnol
PMCID: 5683351
PMID: 28892078
DOI: 10.1038/nbt.3955
call_split See protocol

[…] mentation or were generously given by the laboratory of Dr. Nathanael Gray (Harvard Medical School). An estimator of the response to drugs (AUC: Area Under the dose response Curve) was obtained using drexplorer 1.1.0 in R (R3.1.0).Gene Ontology (GO) category analysis of proteins with dysregulated protein-protein associations enriched in cells of either basal or luminal subtype were done separately […]

library_books

Polo like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non small cell lung cancer with T790M mutations

2016
Oncotarget
PMCID: 5216995
PMID: 27384992
DOI: 10.18632/oncotarget.10332

[…] CI = 1), or antagonism (CI > 1) with the other.IC50, IC70, and scaled AUC (area under curve) values were estimated using the best-fit dose-response model selected by the residual standard error using drexplorer []. AUC (0 for extreme sensitivity, 1 for extreme resistance) served as a measure of sensitivity reflecting both potency and total level of inhibition. One-way analysis of variance (ANOVA) […]

library_books

Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

2016
PLoS One
PMCID: 4824499
PMID: 27055253
DOI: 10.1371/journal.pone.0152584

[…] vehicle control. Four days later, proliferation was assayed by Cell Titer Glo (Promega, Fitchburg, WI). For single-drug treatments, median inhibitory concentration (IC50) values were estimated by the drexplorer software []. Specifically, for each drug combination (at each dose level), the observed (or experimental) effect of the combination was compared to the predicted additive effect. Data was s […]


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drexplorer institution(s)
Departments of Bioinformatics and Computational Biology, Houston, TX, USA; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA; Thoracic and Head and Neck Medical Oncology and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

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