DrGaP statistics

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Citations per year

Number of citations per year for the bioinformatics software tool DrGaP

Tool usage distribution map

This map represents all the scientific publications referring to DrGaP per scientific context
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Associated diseases


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DrGaP specifications


Unique identifier OMICS_00149
Name DrGaP
Alternative name Driver Genes and Pathways
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
License GNU General Public License version 2.0
Computer skills Advanced
Version 0.1.0
Stability Stable
Maintained Yes


No version available



  • person_outline Pengyuan Liu

Publication for Driver Genes and Pathways

DrGaP citations


Applying Expression Profile Similarity for Discovery of Patient Specific Functional Mutations

PMCID: 5876532
PMID: 29485617
DOI: 10.3390/ht7010006

[…] t cancer patients to carry at least one of these 10 predicted driver mutations, covering about 79% of all the patients.In , we also show the driver cancer genes predicted by MutSigCV [], MUSIC [] and drGAP []. We found that 8 out of 10 functional mutated genes were predicted to be driver cancer genes by at least one of three tools at a cutoff of p<0.05. Two transcriptional regulators, including RU […]


Comprehensive characterization of cancer genes in hepatocellular carcinoma genomes

PMCID: 5777097
PMID: 29434842
DOI: 10.3892/ol.2017.7521

[…] a () and glioma (). Therefore, these genes may be ideal candidates for the development of HCC prognostic indicators in future studies.In summary, our group have successfully compiled a list of cancer driver genes and pathways in HCC, enhancing our understanding of pathogenesis and progression of HCC. Furthermore, the novel driver genes and pathways identified by the present study pave the way for […]


Integrated genomic characterization of cancer genes in glioma

PMCID: 5640938
PMID: 29046615
DOI: 10.1186/s12935-017-0458-y

[…] Driver gene candidates were predicted by five distinct tools, including OncodriveCLUST [], OncodriveFM [] (https://www.intogen.org), drgap [] (https://code.google.com/archive/p/drgap), icages [] (http://icages.wglab.org/) and Dendrix [] (http://compbio.cs.brown.edu/projects/dendrix/) with default parameters. The following criteria […]


The NF1 somatic mutational landscape in sporadic human cancers

Hum Genomics
PMCID: 5480124
PMID: 28637487
DOI: 10.1186/s40246-017-0109-3

[…] pathway level. However, a great deal of evidence indicates that multiple pathways often function cooperatively in carcinogenesis and other key biological processes. A common and restricted number of driver genes and pathways are probably responsible for most common forms of cancer [, ].In general, mutations of the genes in one pathway usually exhibit mutual exclusivity, because a single mutation […]


Precision medicine for hepatocellular carcinoma: driver mutations and targeted therapy

PMCID: 5589693
PMID: 28903454
DOI: 10.18632/oncotarget.18382

[…] t making it difficult to propose a standardized management strategy for HCC. Thus, the future therapy direction of HCC will be focused on personalized medicine and it is essential to exactly identify driver genes and pathways in different HCC patients. The two crucial approaches for recognizing driver genes are based on mutation frequency and functional impact on its encoding proteins. The frequen […]


Characterization of potential driver mutations involved in human breast cancer by computational approaches

PMCID: 5564847
PMID: 28477017
DOI: 10.18632/oncotarget.17225

[…] ct the prompt driver genes and their functional domains []. Computational modeling, gene pathway and network analysis are other feasible techniques proposed to identify most probable driver genes []. DrGaP is a tool that predicts driver genes and their signaling pathway using statistical analysis []. Apart from aforesaid tools, many viable techniques, tools, and databases provide significant drive […]

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DrGaP institution(s)
Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA

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