DrGaP statistics

info info

Citations per year


Popular tool citations

chevron_left Driver mutation prioritization Driver pathway detection chevron_right

Tool usage distribution map

Tool usage distribution map
info info

Associated diseases

Associated diseases
Want to access the full stats & trends on this tool?

DrGaP specifications


Unique identifier OMICS_00149
Name DrGaP
Alternative name Driver Genes and Pathways
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
License GNU General Public License version 2.0
Computer skills Advanced
Version 0.1.0
Stability Stable
Maintained Yes


No version available



  • person_outline Pengyuan Liu <>

Publication for Driver Genes and Pathways

DrGaP citations


Applying Expression Profile Similarity for Discovery of Patient Specific Functional Mutations

PMCID: 5876532
PMID: 29485617
DOI: 10.3390/ht7010006

[…] patients to carry at least one of these 10 predicted driver mutations, covering about 79% of all the patients., in , we also show the driver cancer genes predicted by mutsigcv [], music [] and drgap []. we found that 8 out of 10 functional mutated genes were predicted to be driver cancer genes by at least one of three tools at a cutoff of p<0.05. two transcriptional regulators, […]


Comprehensive characterization of cancer genes in hepatocellular carcinoma genomes

PMCID: 5777097
PMID: 29434842
DOI: 10.3892/ol.2017.7521

[…] this, integrated analyses were conducted on these novel cancer driver genes. a total of 112,980 somatic mutations were retrieved from tcga and classified into 11 categories based on their function. driver genes and pathways were predicted by oncodrivefm and dendrix, followed by differential expression, dna-methylation, copy number variations and survival analyses. overall, non-synonymous […]


Integrated genomic characterization of cancer genes in glioma

PMCID: 5640938
PMID: 29046615
DOI: 10.1186/s12935-017-0458-y

[…] are caused by the acquisition of somatic mutations. numerous efforts have been made to characterize the key driver genes and pathways in glioma, however, the etiology of glioma is still not completely known. this study was implemented to characterize driver genes in glioma independently of somatic mutation […]


Construction of miRNA miRNA networks revealing the complexity of miRNA mediated mechanisms in trastuzumab treated breast cancer cell lines

PMCID: 5628841
PMID: 28981542
DOI: 10.1371/journal.pone.0185558

[…] the complexity of mirna mediated drug mechanisms due to the absence of information on the regulatory interaction networks., network analysis is one of the widely adopted approaches to discover driver genes and pathways in biological systems []. recent studies have shown that mirna networks have synergistic roles in the regulation of pathological conditions. if two mirnas interact […]


The NF1 somatic mutational landscape in sporadic human cancers

PMCID: 5480124
PMID: 28637487
DOI: 10.1186/s40246-017-0109-3

[…] pathway level. however, a great deal of evidence indicates that multiple pathways often function cooperatively in carcinogenesis and other key biological processes. a common and restricted number of driver genes and pathways are probably responsible for most common forms of cancer [, ]., in general, mutations of the genes in one pathway usually exhibit mutual exclusivity, because a single […]


Aptamer mediated impairment of EGFR integrin αvβ3 complex inhibits vasculogenic mimicry and growth of triple negative breast cancers

PMCID: 5397976
PMID: 28425453
DOI: 10.1038/srep46659

[…] a mesenchymal-like, a mesenchymal stem-like (msl), and a luminal androgen receptor subtype, the last being characterized by androgen receptor signaling. gene ontologies of these subtypes suggest driver genes and pathways that predict response to therapy. accordingly, basal-like subtypes, showing enrichment of proliferation genes, have a better response to taxane-based therapies as compared […]

Want to access the full list of citations?
DrGaP institution(s)
Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA

DrGaP reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review DrGaP