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Incorporates approximately 6000 cases of exome-seq data, in addition to annotation databases and published bioinformatics algorithms dedicated to driver gene/mutation identification. The database provides two points of view, 'Cancer' and 'Gene', to help researchers visualize the relationships between cancers and driver genes/mutations. In the updated DriverDBv2 database, we incorporated >9500 cancer-related RNA-seq datasets and >7000 more exome-seq datasets from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and published papers. Furthermore, there are two main new features, 'Expression' and 'Hotspot', in the 'Gene' section. 'Expression' displays two expression profiles of a gene in terms of sample types and mutation types, respectively. 'Hotspot' indicates the hotspot mutation regions of a gene according to the results provided by four bioinformatics tools. A new function, 'Gene Set', allows users to investigate the relationships among mutations, expression levels and clinical data for a set of genes, a specific dataset and clinical features.


A resource for the cancer research community that facilitates interrogation of a substantial amount of data from genome-wide analyses. The current version contains data from almost 800 independent experiments studying transcriptomic alterations, genomic gains and losses and somatic mutation information. We designed the system to incorporate data from new experiments and from other alteration types when available (for example, epigenomic and proteomic data). IntOGen bridges the gap between biological and clinical information in cancer.


A graph database for storage and querying of conditional relationships between molecular events observed at different stages of colorectal oncogenesis. EpiGeNet integrates a Neo4j-based framework to capture and explore semantic relationships observed at different pathological levels in colorectal cancer development and to manage genetic–epigenetic interdependencies. In a graph database, concepts are represented by nodes and their associations by edges. EpiGeNet provides a more natural way of representing highly interconnected data, with exploration of stored content benefitting additionally from the use of different graph algorithms.

CanDL / Cancer Driver Log

Hosts driver mutations in cancers that are potentially actionable to support annotation in clinical genomic testing laboratories by molecular pathologists, laboratory directors, and bioinformaticians. CanDL database contains mutations in 56 genes with 330 distinct variants with 160 unique matching references across multiple cancers. Entries can be searched by gene(s) or by amino acid variants, or downloaded for custom analyses. Although the default output includes normal amino acid, peptide position, variant amino acid, cancer type, and the reference for a given gene, users have the option to customize output to include additional information (eg, exon, mutation coding DNA sequence, transcript). The users can either upload candidate mutations or download the entire log from the website.