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DriverDB

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Incorporates approximately 6000 cases of exome-seq data, in addition to annotation databases and published bioinformatics algorithms dedicated to driver gene/mutation identification. The database provides two points of view, 'Cancer' and 'Gene', to help researchers visualize the relationships between cancers and driver genes/mutations. In the updated DriverDBv2 database, we incorporated >9500 cancer-related RNA-seq datasets and >7000 more exome-seq datasets from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and published papers. Furthermore, there are two main new features, 'Expression' and 'Hotspot', in the 'Gene' section. 'Expression' displays two expression profiles of a gene in terms of sample types and mutation types, respectively. 'Hotspot' indicates the hotspot mutation regions of a gene according to the results provided by four bioinformatics tools. A new function, 'Gene Set', allows users to investigate the relationships among mutations, expression levels and clinical data for a set of genes, a specific dataset and clinical features.

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DriverDB classification

  • Animals
    • Homo sapiens

DriverDB specifications

Restrictions to use:
None
Data access:
Browse
Maintained:
Yes
Database management system:
MySQL
Version:
2.0

Credits

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Publications

Institution(s)

Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan; Center for Systems and Synthetic Biology, National Yang-Ming University, Taipei, Taiwan; Research Center for Tumour Medical Science, China Medical University, Taichung, Taiwan; Department of Genome Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan; VGH-YM Genomic Research Center, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, Medical College, National Yang-Ming University, Taipei, Taiwan; Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan; Department of Education and Research, Taipei City Hospital, Taipei, Taiwan

Funding source(s)

Ministry of Science and Technology (MOST) [104-2221-E-010-012, 104-2320-B-039-053]; China Medical University, Taiwan [CMU104-N-14]; National Yang-Ming University, Taiwan (a grant from the Ministry of Education, Aim for the Top University Plan)

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