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Drug–drug interaction (DDI) is a situation when one drug increases or decreases the effect of another drug (Tari et al., 2010). Information about DDIs is crucial for drug administration to avoid adverse drug reactions or therapeutic failure (van Roon et al., 2009). For example, a recent study reports that DDIs are a significant cause of hospital admissions (Dechanont et al., 2014).
(Tari et al., 2010) Discovering drug-drug interactions: a text-mining and reasoning approach based on properties of drug metabolism. Bioinformatics.
(van Roon et al., 2009) An evidence-based assessment of the clinical significance of drug-drug interactions between disease-modifying antirheumatic drugs and non-antirheumatic drugs according to rheumatologists and pharmacists. Clin Ther.
(Dechanont et al., 2014) Hospital admissions/visits associated with drug-drug interactions: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf.
(Bui et al., 2014) A novel feature-based approach to extract drug-drug interactions from biomedical text. Bioinformatics.