Gathers detailed drug, drug-target, drug action and drug interaction information about drugs. DrugBank is a web resource that contains information about FDA-approved drugs as well as experimental drugs going through the FDA approval process. The database also includes pharmaco-omic data covering the influence of drugs on metabolite levels, gene expression levels and protein expression levels, as well as data on investigational drug clinical trials and drug repurposing trials, and thousands of up-to-date drug images of approved drugs.
A database of drug-induced pathways, which was generated by KEGG pathway enrichment analysis for drug-induced upregulated genes and downregulated genes based on drug-induced gene expression datasets in Connectivity Map. Drug-Path provides user-friendly interfaces to retrieve, visualize and download the drug-induced pathway data in the database. In addition, the genes deregulated by a given drug are highlighted in the pathways. All data were organized using SQLite. The web site was implemented using Django, a Python web framework.
Presents disease relationships from the viewpoint of gene regulation mechanism. DNetDB records common dysfunctional regulation mechanism, common disease-related genes and drugs of disease pairs. In this way, DNetDB has the capability to support pathogenesis exploration, drug repositioning and drug development. It provides an easy-to-use web interface to search and browse disease relationships through disease name(s), disease gene, drug, GSE ID(s), and tissue (s). DNetDB facilitates the study of disease relationships and provides insightful clues to investigate diseases’ etiology and pathogenesis, perform drug repositioning, and design novel therapeutic interventions.
Detects mutual drug impairments and helps to appraise the drug response. Transformer is a comprehensive resource that combines scientific information on phase I and phase II reactions of enzymes, transporter enzymes, prodrugs, food and herbs that increase risk of adverse drug reactions. This resource can be a sound starting point for further research in drug interactions.
Contains a comprehensive list of computer-aided drug design (CADD) software, databases and web services. Click2Drug classifies tools according to their application field, trying to cover the whole drug design pipeline. Users can enhance the database. It contains around 721 tools links.
Compiles information about yeast chemogenomic screening data. NetwoRx integrates three larges chemogenomic experiments, covering nearly 6000 yeast genes and about 460 drugs. Moreover, the database includes pathways and phenotypes targeted by drugs, computes drug–drug similarity metrics for mode of action analysis and build drug–phenotype networks extracted from fours genes sets collections. Users can also query new gene lists against the entire collection of drug profiles to retrieve the drugs that target them.