Aims to discover new indications for existing drugs with known safety profiles. Drug Repurposing Hub is an interactive website designed to rapidly identify drugs for evaluation in disease models. The Hub consists of (i) a physical drug screening library available in multiple plate formats at the Broad Compound Management facility, (ii) manually curated annotations as part of a comprehensive publicly-accessible information resource with data API, and (iii) experimental results with liquid chromatography-mass spectrometry (LC-MS) tracings and future cellular assays.
Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA
Drug Repurposing Hub funding source(s)
This work was supported in part by NIH LINCS Program grants 3U54 HG006093, U54 HL127366, and U54 HG008699, the Howard Hughes Medical Institute, NIH training grant T32 CA009172, KL2/Catalyst Medical Research Investigator Training award from Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health) Award KL2 TR001100 and the Conquer Cancer Foundation of ASCO Young Investigator Award.