Provides a collection of the MultiCellDS files. MultiCellDB contains digital cells lines and permits users to upload DCL files which are stored in their original form, as well as converted into an entity-relationship model for storage in a relational database. It is browsable by phenotype, measurement value, microenvironment, or metadata value. The MultiCellDS format offers metadata to assist curation, particularly when aggregating measurements from many laboratories.
Provides a compilation of gene expression, chromosomal copy number, and massively parallel sequencing data from human cancer cell lines. The resulting collection encompasses 36 tumor types. The mutational status of more than 1,600 genes is determined by targeted massively parallel sequencing, followed by removal of variants likely to be germline events. CCLE has been aggregated to facilitate numerous advances in cancer biology and drug discovery. It also may help to enable preclinical stratification schemata for anticancer agents.