Provides a compilation of gene expression, chromosomal copy number, and massively parallel sequencing data from human cancer cell lines. The resulting collection encompasses 36 tumor types. The mutational status of more than 1,600 genes is determined by targeted massively parallel sequencing, followed by removal of variants likely to be germline events. CCLE has been aggregated to facilitate numerous advances in cancer biology and drug discovery. It also may help to enable preclinical stratification schemata for anticancer agents.