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DSEA / Drug-Set Enrichment Analysis
Detects molecular pathways that are consistently up- or down- regulated by a set of drugs. By diluting drug-specific effects unrelated to the phenotype of interest, DSEA is able to highlight phenotype-specific pathways, thus helping to formulate hypotheses on the mechanism of action (MoA) shared by the drugs in the set. Given a query-set of small-molecules, DSEA checks for each pathway whether small-molecules tend to be significantly ranked at the top (or the bottom) of the list, by applying a Kolmogorov-Smirnov (KS) test. An Enrichment Score for the drug-set and a p-value can thus be computed for each pathway exactly, without the need of random permutations.
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