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Citations per year

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Drug2Gene specifications


Unique identifier OMICS_03418
Name Drug2Gene
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained No


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Publication for Drug2Gene

Drug2Gene citations


A Systems Approach Implicates a Brain Mitochondrial Oxidative Homeostasis Co expression Network in Genetic Vulnerability to Alcohol Withdrawal

Front Genet
PMCID: 5206817
PMID: 28096806
DOI: 10.3389/fgene.2016.00218

[…] member human homologs: ACTA2, CHKA, HSPA5, ID2, JAK1, MAP2K1, PCNA, and YWHAZ. Of these 835 genes, 48 are annotated as “response to oxidative stress” (GO:0006979, p = 5.8 × 10-23). Another database, Drug2gene (), shows evidence of 387 human NAC-affected genes, including R8B6green module homologs: HSPA5, JAK1, PCNA, TFRC, and CALR. Of these 387 genes, 38 are annotated as “response to oxidative str […]


High dimensional omics data analysis using a variable screening protocol with prior knowledge integration (SKI)

BMC Syst Biol
PMCID: 5260139
PMID: 28155690
DOI: 10.1186/s12918-016-0358-0

[…] ssion, mutation data, and copy numbers. In total there were 489 cell lines and 41,872 genomic features measured. For a single feature, we assign a specific gene annotation on it. We then searched the Drug2Gene database [] to acquire prior knowledge of association between selumetinib and genes. Drug2Gene is an integrative knowledge base reporting relations between genes/proteins and drugs/compounds […]


Carboplatin induced hematotoxicity among patients with non small cell lung cancer: Analysis on clinical adverse events and drug gene interactions

PMCID: 5458280
PMID: 27802181
DOI: 10.18632/oncotarget.12951
call_split See protocol

[…] The information of relations between carboplatin and genes/proteins was retrieved from Drug2Gene (http://www.drug2gene.com), a freely accessible knowledge base that combined data from 23 public databases to provide a ‘one-stop shop’ for finding all genes related to a certain drug. By se […]


Proteome wide drug screening using mass spectrometric imaging of bead arrays

Sci Rep
PMCID: 4872124
PMID: 27194112
DOI: 10.1038/srep26125

[…] 50 >100 nM; medium for ≤100 nM and >10 nM; and strong for ≤10 nM. Since Bead-GPS measures binding, Kd values were used instead of IC50 when available. For Dasatinib, Kd values were available from the Drug2Gene database for 42 kinases. Bead-GPS results for Dasatinib for these kinases are shown in . The known weak interactions give consistently zero or negligible MALDI-MS Dasatinib signals, while th […]


Building a virtual ligand screening pipeline using free software: a survey

Brief Bioinform
PMCID: 4793892
PMID: 26094053
DOI: 10.1093/bib/bbv037

[…] et effects []. To collect information on the known protein–ligand interactions for a receptor or small molecule of interest, lists the main relevant databases, most of which are publicly accessible. Drug2Gene [], the currently most comprehensive meta-database, may provide a first point of reference for most types of queries. Other repositories have a more specific scope, e.g. PDBbind [] focuses e […]

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Drug2Gene institution(s)
Bayer Pharma AG, Berlin, Germany

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