DrugEBIlity statistics

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DrugEBIlity specifications


Unique identifier OMICS_19740
Name DrugEBIlity
Software type Application/Script
Interface Web user interface
Restrictions to use None
License Creative Commons - Attribution Share-Alike 3.0 Unported license
Computer skills Basic
Stability Stable
Maintained Yes

Additional information


DrugEBIlity citations


Guanylate binding protein 1 is a potential new therapeutic target for triple negative breast cancer

BMC Cancer
PMCID: 5688804
PMID: 29115931
DOI: 10.1186/s12885-017-3726-2

[…] nformation, 42 of which presented structure-based druggability (Fig. ), as they showed potential small molecule binding pockets in an analysis based on the ChEMBL Strudel https://www.ebi.ac.uk/chembl/drugebility/) (DrugEBIlity) methodology. Among these genes, 10 exhibited ligand-based druggability scores falling within the 75% percentile or above defined for all of the proteins in the platform (Fi […]


Genome wide analysis of excretory/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome

PMCID: 4696181
PMID: 26715441
DOI: 10.1186/s13071-015-1282-7

[…] were further screened for sequence similarities against the known drug targets. Drug target sequences were extracted from the following databases: 1. ChEMBL (ftp://ftp.ebi.ac.uk/pub/databases/chembl/DrugEBIlity/releases/3.0/), 16072 drug target protein sequences and 212919 domain sequences; 2. DrugBank (http://www.drugbank.ca/), 3789 proteins; 3. Therapeutic Targets Database (http://bidd.nus.edu. […]


Comparative transcriptomics reveals striking similarities between the bovine and feline isolates of Tritrichomonas foetus: consequences for in silico drug target identification

BMC Genomics
PMCID: 4247702
PMID: 25374366
DOI: 10.1186/1471-2164-15-955

[…] []. Parasite transcripts that did not produce a common Blast hit with their respective host were extracted and queried in a further BlastX against known druggable domains retrieved from the ChEMBL’s DrugEBility database (e-value 0.0001) []. Positive hits were matched with domain information to identify which transcripts contain domains that satisfy Lipinski ‘rule of 5’ of druggability []. […]


Strategic genome scale prioritization of unique drug targets: A case study of Streptococcus gordonii

PMCID: 3867652
PMID: 24391362
DOI: 10.6026/97320630009983

[…] o Undruggable: -1.0 was analyzed. Only positive scores of ensemble were considered as they are valuable representations of conformational flexibility of protein structures.Restricting the results of ‘DrugEBIlity’ scores to 73 proteins, 57 were excluded. Remaining 16 proteins were further explored with literature search ensuring 9 as potent drug targets, 3 associated with at least one of the signif […]


MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease Associated Molecular Pathways

PMCID: 3712543
PMID: 23875173
DOI: 10.3389/fonc.2013.00184

[…] e cases, such as statistical associations between RNA expression and patient survival, a cut-off was required for defining gene set membership. For example, only genes encoding proteins with positive DrugEBIlity ensemble scores were included in the gene set “DrugEBIlity: Positive ensemble scores.” A further description of the melanoma gene sets is available in Data Sheet 1 in Supplementary Materia […]


Discovery 2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria

Malar J
PMCID: 3637051
PMID: 23537208
DOI: 10.1186/1475-2875-12-116

[…] and protein ligand interactions. The new functionalities are the addition of expression information, literature information from PubMed abstracts, the implementation of druggability predictions from DrugEBIlity where available, the inclusion of malaria-related data from the clinical trials database and the implementation of Wiki-like user annotations. Specific advantages of Discovery-2 include ex […]


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