DrugEBIlity statistics

info info

Citations per year

Number of citations per year for the bioinformatics software tool DrugEBIlity
info

Tool usage distribution map

This map represents all the scientific publications referring to DrugEBIlity per scientific context
info info

Associated diseases

info

Popular tool citations

chevron_left Structure-based virtual screening chevron_right
Want to access the full stats & trends on this tool?

Protocols

DrugEBIlity specifications

Information


Unique identifier OMICS_19740
Name DrugEBIlity
Software type Application/Script
Interface Web user interface
Restrictions to use None
License Creative Commons - Attribution Share-Alike 3.0 Unported license
Computer skills Basic
Stability Stable
Maintained Yes

Additional information


http://chembl.blogspot.fr/2010/10/drugebility-structure-based-component.html

DrugEBIlity citations

 (7)
library_books

Guanylate binding protein 1 is a potential new therapeutic target for triple negative breast cancer

2017
BMC Cancer
PMCID: 5688804
PMID: 29115931
DOI: 10.1186/s12885-017-3726-2

[…] nformation, 42 of which presented structure-based druggability (Fig. ), as they showed potential small molecule binding pockets in an analysis based on the ChEMBL Strudel https://www.ebi.ac.uk/chembl/drugebility/) (DrugEBIlity) methodology. Among these genes, 10 exhibited ligand-based druggability scores falling within the 75% percentile or above defined for all of the proteins in the platform (Fi […]

library_books

Genome wide analysis of excretory/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome

2015
PMCID: 4696181
PMID: 26715441
DOI: 10.1186/s13071-015-1282-7

[…] were further screened for sequence similarities against the known drug targets. Drug target sequences were extracted from the following databases: 1. ChEMBL (ftp://ftp.ebi.ac.uk/pub/databases/chembl/DrugEBIlity/releases/3.0/), 16072 drug target protein sequences and 212919 domain sequences; 2. DrugBank (http://www.drugbank.ca/), 3789 proteins; 3. Therapeutic Targets Database (http://bidd.nus.edu. […]

library_books

Comparative transcriptomics reveals striking similarities between the bovine and feline isolates of Tritrichomonas foetus: consequences for in silico drug target identification

2014
BMC Genomics
PMCID: 4247702
PMID: 25374366
DOI: 10.1186/1471-2164-15-955

[…] []. Parasite transcripts that did not produce a common Blast hit with their respective host were extracted and queried in a further BlastX against known druggable domains retrieved from the ChEMBL’s DrugEBility database (e-value 0.0001) []. Positive hits were matched with domain information to identify which transcripts contain domains that satisfy Lipinski ‘rule of 5’ of druggability []. […]

library_books

Strategic genome scale prioritization of unique drug targets: A case study of Streptococcus gordonii

2013
Bioinformation
PMCID: 3867652
PMID: 24391362
DOI: 10.6026/97320630009983

[…] o Undruggable: -1.0 was analyzed. Only positive scores of ensemble were considered as they are valuable representations of conformational flexibility of protein structures.Restricting the results of ‘DrugEBIlity’ scores to 73 proteins, 57 were excluded. Remaining 16 proteins were further explored with literature search ensuring 9 as potent drug targets, 3 associated with at least one of the signif […]

library_books

MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease Associated Molecular Pathways

2013
PMCID: 3712543
PMID: 23875173
DOI: 10.3389/fonc.2013.00184

[…] e cases, such as statistical associations between RNA expression and patient survival, a cut-off was required for defining gene set membership. For example, only genes encoding proteins with positive DrugEBIlity ensemble scores were included in the gene set “DrugEBIlity: Positive ensemble scores.” A further description of the melanoma gene sets is available in Data Sheet 1 in Supplementary Materia […]

library_books

Discovery 2: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria

2013
Malar J
PMCID: 3637051
PMID: 23537208
DOI: 10.1186/1475-2875-12-116

[…] The “Druggability” tab displays the results of BLAST searches against domains and proteins sequences in the DrugEBIlity database. […]


Want to access the full list of citations?

DrugEBIlity reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review DrugEBIlity