Recognizes conformational variations from a single X-ray structure and thereby may assist predictions of functionally important residues. DSSPcont is able to distinguish well-defined from rigged helix/strand caps. It differentiates non-regular states that are flexible from those that are not. The DSSPcont predictions for all Protein Data Bank (PDB) entries have been integrated into the database integration system Sequence Retrieval System (SRS). Users can upload a file containing a protein or ‘cut and paste’ the protein description into the web interface.
CUBIC, Department of Biochemistry and Molecular Biophysics and 2 North East Structural Genomics Consortium (NESG), Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA; BASF AG, Ludwigshafen, Germany; Structural Bioinformatics Group, Department of Biological Sciences, Imperial College, London, UK; Columbia University Center for Computational Biology and Bioinformatics (C2B2), Russ Berrie Pavilion, New York, NY, USA
DSSPcont funding source(s)
Supported by the grants 1-P50- GM62413-01 and RO1-GM63029-01 from the National Institute of Health (NIH).