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DSSTox specifications


Unique identifier OMICS_07759
Name DSSTox
Alternative name Distributed Structure-Searchable Toxicity
Restrictions to use None
Version 2.0
Maintained Yes

Publications for Distributed Structure-Searchable Toxicity

DSSTox citations


Beyond genomics: understanding exposotypes through metabolomics

Hum Genomics
PMCID: 5787293
PMID: 29373992
DOI: 10.1186/s40246-018-0134-x

[…] (https://metlin.scripps.edu), another large database containing 961,829 metabolites, recently expanded due to the integration of xenobiotics from the United States Environmental Protection Agency’s “Distributed Structure-Searchable Toxicity (DSSTox)” database [, ]. The Exposome-Explorer database was recently designed to contain information on biomarkers of exposure to environmental risk factors f […]


CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

Environ Health Perspect
PMCID: 4937869
PMID: 26908244
DOI: 10.1289/ehp.1510267

[…] th exposure potential (~ 43,000). Available in the U.S. EPA chemical product categories database (CPCat), which is part of the Aggregated Computational Toxicology Resource (ACToR) system (; , ; ).The Distributed Structure-Searchable Toxicity (DSSTox) (). A list of ~ 15,000 curated chemical structures from multiple inventories of environmental interest. In particular, structures for all of the ToxC […]


In silico toxicology: computational methods for the prediction of chemical toxicity

PMCID: 4785608
PMID: 27066112
DOI: 10.1002/wcms.1240
call_split See protocol

[…] c toxicity, reproductive toxicity, skin sensitization, and environmental toxicity. Examples of tools implementing read‐across are The OECD QSAR Toolbox, Toxmatch, ToxTree, AMBIT, AmbitDiscovery, AIM, DSSTox, or ChemIDplus. A detailed explanation of some of these tools is available in refs. , , , , , , , . […]


Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

Int J Mol Sci
PMCID: 3291995
PMID: 22408426
DOI: 10.3390/ijms13021805

[…] well into the basic ACToR assay table structure. However, because the ToxCast HTS assays are all run in concentration-response mode, ToxCastDB must additionally capture these individual data points. DSSTox is providing structure annotations and chemical sample details for ToxCast; hence, a MySQL version of the ToxCast DSSTox data is included here. Chemical sample details include testing-related i […]


AMBIT RESTful web services: an implementation of the OpenTox application programming interface

J Cheminform
PMCID: 3120779
PMID: 21575202
DOI: 10.1186/1758-2946-3-18

[…] ad:9 a ot:Dataset ;   rdfs:seeAlso "http://www.epa.gov/NCCT/dsstox/sdf_isscan_external.html" ;   dc:source "ISSCAN_v3a_1153_19Sept08.1222179139.sdf" ;   dc:title "ISSCAN: Istituto Superiore di Sanita, CHEMICAL CARCINOGENS: STRUCTURES AND EXPERIMENTAL DATA".af: […]


A Model Based Prioritisation Exercise for the European Water Framework Directive

PMCID: 3084470
PMID: 21556195
DOI: 10.3390/ijerph8020435

[…] rning several physico-chemical properties, and we have queried Footprint [] (chronic/acute data NOECs, EC50; various taxa for pesticides), ECETOC (chronic/acute data NOECs, EC50, various taxa) [] and DSSTOX (acute toxicity data for fish, EC50) [] for mining toxicity experimental data. Finally, to apply the ECETOC TRA tool [], we have collected also data concerning use assessment for 827 and for 30 […]


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DSSTox institution(s)
National Center for Computational Toxicology, Office of Research and Development, US EPA, Research Triangle Park, NC, USA

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