dSysMap specifications


Unique identifier OMICS_07902
Name dSysMap
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • Primates
    • Homo sapiens


  • person_outline dSysMap <>

Publication for dSysMap

dSysMap in publications

PMCID: 5623905
PMID: 28945216
DOI: 10.1038/oncsis.2017.79

[…] the energetic impact of a mutation on the stability of a protein or protein complex., , , , , a thorough comparison and discussion of limitations of these methods can be found in references , . dsysmap and mechismo extrapolate interactions observed in 3d structures to interactions of homologous proteins. we have recently presented structman, a tool that allows for rapid analysis of large […]

PMCID: 5543104
PMID: 28775330
DOI: 10.1038/s41598-017-07351-0

[…] are more likely causing distinct interruptions in the overall interactome. therefore, they can result in different biological phenotypes. in a recent study, mosca et al. created a resource named dsysmap which systematically maps disease-related missense mutations on the structurally annotated human interactome. their study shows that if pairs of mutations are located in different interfaces […]

PMCID: 4926441
PMID: 27338356
DOI: 10.3390/ijms17060907

[…] to interact with each other in the pin. the interaction map of the disorders and disease genes were described as part of diseasome []. with the new trend of structure associated interaction studies, dsysmap was developed as a resource for the map of disease-related mutations which link interactions with protein structures and suggest new connections between disorders []. the close interactions […]

PMCID: 4709589
PMID: 26754054
DOI: 10.1038/srep18716

[…] on phd2. these are: v138a, q157h, p165s, p200q, n203k, d254h, k291i, p317r, r371h, h374r, r398x and k423e. correlation with human diseases (i.e. cancer) was investigated with the structure-ppi and dsysmap tools., following our previous work on phd mutations in cancer, we identified from the literature twelve human phd2 mutants described in polycythemic patients () and weakly correlated […]

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dSysMap institution(s)
Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain

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