Constructs drug-target networks. DTome is a web-based tool to search and integrate drug-target information to generate a DTome network for the candidate drug(s). The software is efficient in generating and integrating drug-drug, drug-target, drug-associated, and target-protein interactions to build a DTome network. Its usefulness was demonstrated constructing a DTome network for the antipsychotic drug clozapine. The softwre’s output provides a starting point to further investigate the molecular mechanisms of drug actions.
Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA; Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
DTome funding source(s)
Partially supported by a 2010 NARSAD Young Investigator Award and the NIH grant NCI R01CA141307.