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e-Driver specifications

Information


Unique identifier OMICS_05288
Name e-Driver
Software type Application/Script, Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Perl
License Apache License version 2.0
Computer skills Advanced
Stability Stable
Maintained Yes

Versioning


No version available

Documentation


Maintainers


  • person_outline Adam Godzik
  • person_outline Joaquín Dopazo

Publications for e-Driver

e-Driver citations

 (8)
library_books

Training and Practices of Cannabis Dispensary Staff

2016
PMCID: 5531366
PMID: 28861496
DOI: 10.1089/can.2016.0024

[…] el/shipping legal advice, dosing guidelines, and ailment or disease-specific information. Those who did not provide advice or counsel indicated that it was not part of their role at the dispensary (i.e., driver or delivery service). None of the dispensary staff members indicated that they provide advice regarding medications or drugs other than cannabis to their patients.Dispensary staff reported […]

library_books

Cell Fusion in the War on Cancer: A Perspective on the Inception of Malignancy

2016
Int J Mol Sci
PMCID: 4964493
PMID: 27420051
DOI: 10.3390/ijms17071118

[…] ysis of DNA sequences in samples of tumors converge to support the idea that tumors arise from the accumulation of random spontaneous mutations that disrupt a finite number of “transforming genes” (i.e., driver mutations) among the vastly more numerous mutations in neutral genes (i.e., passenger mutations) [,,]. This concept appears to draw further support from the relationship between age and the […]

library_books

Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types

2016
BMC Genomics
PMCID: 4928158
PMID: 27356755
DOI: 10.1186/s12864-016-2727-x

[…] Figure S2), which indicated the statistical robustness of our approach.Furthermore, we found significantly overlapped genes between our set with those predicted by other cluster-based methods such as e-Driver [] (151/552 vs 398/24499, Fisher exact test, p = 3.42e-139) and OncodriveCLUST [] (106/489 vs 443/24462, Fisher exact test, p = 2.31e-74). Additionally, regarding the mutational clusters, we […]

library_books

Substantial contribution of extrinsic risk factors to cancer development

2015
Nature
PMCID: 4836858
PMID: 26675728
DOI: 10.1038/nature16166

[…] iven approach to dissecting the risk contribution of the intrinsic processes, we modeled the potential lifetime cancer risk due to intrinsic stem-cell mutation errors by varying the number of hits (i.e. driver gene mutations), denoted by k, required for cancer onset. We derived the probability distribution of the propagation of driver gene mutations from one generation to the next, and subsequentl […]

library_books

The Emerging Role of D 2 Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System Neoplasms

2013
PMCID: 3698461
PMID: 23847760
DOI: 10.3389/fonc.2013.00169

[…] oduction of d-2HG promotes oncogenesis (Koivunen et al., ; Losman et al., ) and therefore IDH1 and IDH2 mutations are likely the integrally involved in the pathogenesis of malignant transformation (i.e., driver mutations) rather than epiphenomena.In this review, we summarize the frequency and role of IDH1 and IDH2 mutations in gliomas and myeloid neoplasms, the latter with an emphasis on AML, and […]

library_books

Synergy in science: an interview with Neal Copeland and Nancy Jenkins

2012
PMCID: 3484853
PMID: 23115200
DOI: 10.1242/dmm.010991

[…] t now is how to sort through all of this heterogeneity and complexity. And the main question is what to target for therapy. You need to target something that is common to most of the cancer cells – i.e. driver mutations, the ones that happen before the majority of branching occurs.Neal: The other possibility is to target the signalling pathways or metabolic pathways that are commonly deregulated i […]

Citations

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e-Driver institution(s)
Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA; European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK; Computational Genomics Department, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain; Functional Genomics Node, (INB) at CIPF, Valencia, Spain; Bioinformatics of Rare Diseases (BIER), CIBER de Enfermedades Raras (CIBERER), Valencia, Spain
e-Driver funding source(s)
Supported by National Institute of Health grant GM101457, grants BIO2014-57291-R from the Spanish Ministry of Economy and Competitiveness (MINECO) and PROMETEOII/2014/025 from the Conselleria de Educacio of the Valencian Community.

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