e-Driver specifications


Unique identifier OMICS_05288
Name e-Driver
Software type Application/Script, Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Perl
License Apache License version 2.0
Computer skills Advanced
Stability Stable
Maintained Yes


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  • person_outline Adam Godzik <>
  • person_outline Joaquín Dopazo <>

Publications for e-Driver

e-Driver in publications

PMCID: 5756345
PMID: 29304754
DOI: 10.1186/s12864-017-4423-x

[…] methods used to identify cancer driver genes, such as activedriver [], dendrix [], mdpfinder [], simon [], netbox [], oncodrivefm [], mutsigcv [], memo [], comdp [], dawnrank [], drivernet [], e-driver [], ipac [], msea [], and oncodriveclust []., we applied driverdb [] to obtain results from all these algorithms and the cancer datasets considered by our computation approach., in silico […]

PMCID: 5415494
PMID: 28492066
DOI: 10.1016/j.heliyon.2017.e00277

[…] lists of the top ranked driver genes determined from the use of 15 packages, including activedriver, dendrix, mdpfinder, simon, netbox, oncodrivefm, mutsigcv, memo, comdp, dawnrank, drivernet, e-driver, ipac, msea, and oncodriveclust. lists the cancer types, sample size, and descriptions of the driver genes used, including chromosome location, gene ontology nomenclature, and molecular […]

PMCID: 4928158
PMID: 27356755
DOI: 10.1186/s12864-016-2727-x

[…] elements. oncodriveclust [] estimates background model from coding-silent mutations and tests protein domains containing clusters of missense mutations that are likely to alter protein structure. e-driver [] uses protein 3d structural features to predict driver genes containing clusters of missense mutations in protein-protein interaction (ppi) interfaces. however, increasingly more studies […]

PMCID: 4480958
PMID: 26111056
DOI: 10.1186/1471-2164-16-S8-S7

[…] from the protein data bank []. the idea is to study the impact of missense somatic mutations on protein three-dimensional structure. the cancer3d database includes predictions from e-drug and e-driver, two recently developed tools for predicting sensitivity to 24 anticancer compounds and cancer driver proteins []., in the last few years, several web portals have been developed […]

PMCID: 4092873
PMID: 24939987
DOI: 10.7554/eLife.02780.014

[…] anticipation to the arrhythmic per01 strain (), indicating an important role of these cells in circadian behavior. the five e cells labeled with dvpdf-gal4, pdf-gal80 (henceforth called the dv-e driver and the dv-e cells) project to the dorsal brain and to the accessory medulla (ame) as previously described (, arrows) (); the latter is based on a projection from the e cells, which contacts […]

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e-Driver institution(s)
Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA; European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK; Computational Genomics Department, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain; Functional Genomics Node, (INB) at CIPF, Valencia, Spain; Bioinformatics of Rare Diseases (BIER), CIBER de Enfermedades Raras (CIBERER), Valencia, Spain
e-Driver funding source(s)
Supported by National Institute of Health grant GM101457, grants BIO2014-57291-R from the Spanish Ministry of Economy and Competitiveness (MINECO) and PROMETEOII/2014/025 from the Conselleria de Educacio of the Valencian Community.

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