Computational protocol: The Effects of Alcohol Intoxication on Neuronal Activation at Different Levels of Cognitive Load

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Protocol publication

[…] The working memory n-back task used [,] contained three separate runs, presented with an increase in cognitive load (1-back, 2-back and 3-back). In each run, single digits, from 1 to 9 were shown in the LCD goggles (NordicNeuroLab Inc., Norway) that the participants wore during the scanning session. Participants responded by pressing a response button on an electronic response grip (NordicNeuroLab Inc., Norway) held in their right hand whenever the presented digit was the same as the digit presented 1, 2 or 3 steps earlier in the sequence, depending on the instruction given (Fig. ). A block-design with six alternating ON and OFF blocks was used in each run, and each block lasted for 37.5 sec. Each ON-block consisted of presentation of 15 digits, giving a total of 90 digits per run. There were 3 target stimuli within each ON block, resulting in 20% target stimuli in each run. Each digit was presented for 300 ms, with a 2200 ms black screen between presentations. The OFF-blocks contained a black screen with the same duration as the ON-blocks, but with no task to perform.The digit stimuli were programmed and presented with the E-Prime experiment control programming platform (Psychological Software Tools Inc., Great Britain). The timing of stimulus presentations was synchronized with the scanner image volume acquisition timing using a synchronization toolbox (NordicNeuroLab Inc., Norway). Response time (RT) and response accuracy (RA) were recorded and stored for subsequent off-line statistical analysis. [...] One-way ANOVA and Tukey’s HSD post-hoc test were used to analyze group differences in RA and RT, and in blood Glu and Hb levels (Statistica 7.0, StatSoft Inc. USA). […]

Pipeline specifications

Software tools E-Prime, Statistica
Applications Miscellaneous, Neuropsychology analysis
Organisms Homo sapiens
Diseases Alcoholic Intoxication
Chemicals Ethanol