Computational protocol: Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants

Similar protocols

Protocol publication

[…] For test performance analyses, results of samples (all baseline samples, all samples per DOAC) were pooled in order to obtain a clinically relevant concentration spectrum. SPSS v23 (IBM, Armonk, NY, USA) was used for statistics. Confidence intervals for proportions, i.e. diagnostic sensitivity and specificity, were calculated according to the efficient-score method using the free online VassarStats Clinical Calculator 1 []. Pearson’s correlation coefficient was used to estimate the strength of correlations between coagulation assays and DOAC concentrations. Correlation strength was graded as proposed by Evans: <0.20 very weak, 0.20–0.39 weak, 0.40–0.59 moderate, 0.60–0.79 strong, and >0.80 very strong []. Fisher’s exact test was calculated to determine differences in the proportions of baseline POCT results between the study groups and to examine the association between coagulation test results and DOAC concentrations dichotomized to concentrations below and above the chosen safe-for-treatment thresholds (Table ). Diagnostic accuracy of coagulation tests at different cut-off points was expressed in terms of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and likelihood ratio. Sensitivity was defined as the percentage of samples with DOAC concentrations below the chosen safe-for-treatment threshold that were correctly identified as eligible for treatment. Correspondingly, specificity was defined as the percentage of samples with DOAC concentrations above the corresponding threshold that were correctly identified as not eligible. Specificity >95% was defined as sufficient for clinical application. PPV was defined as the percentage of samples with DOAC concentrations below the chosen safe-for-treatment threshold of all samples identified as eligible for treatment. NPV was defined as the percentage of samples with DOAC concentrations above the chosen safe-for-treatment threshold of all samples identified as not eligible for treatment. All DOAC concentrations are reported as median and interquartile range (IQR). Sensitivity and specificity are given with two-sided 95% confidence intervals. […]

Pipeline specifications

Software tools SPSS, VassarStats
Application Miscellaneous
Organisms Homo sapiens