Computational protocol: Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome

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Protocol publication

[…] The frequencies of genotypes, alleles, and haplotypes of the CRHR2 SNPs were compared between the IBS patients and controls, or between patients with different bowel patterns (normal, constipation, mixed, and diarrhea) using the χ2-test. The effects of variation in CRHR2 SNPs and haplotypes on psychological states between the IBS patients and controls were examined with two-way analysis of variance (ANOVA). The effects of variation in CRHR2 haplotypes on psychological states were examined with one-way ANOVA. Statistical analyses were performed using SPSS Statistics version 21.0 software (IBM, Inc., New York, NY). We used Haploview [] to determine the LD of the SNPs within the CRHR2 gene and test for Hardy–Weinberg equilibrium. Results are expressed as the mean ± standard error, and a P value < 0.05 was considered to be significant. […]

Pipeline specifications

Software tools SPSS, Haploview
Applications Miscellaneous, GWAS
Organisms Homo sapiens
Diseases Irritable Bowel Syndrome