Computational protocol: Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins

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Protocol publication

[…] H-2d (H-2Kd, H-2Dd and H-2Ld)-restricted epitopes of SEBOV-GP and ZEBOV-GP were predicted using BIMAS, IEDB (SMM), NetMHC, NetCTLpan, nHLAPred (Compred), PREDEP, ProPred-I and SYFPEITHI (Table ). The top five ranking peptides from each program were selected, and rearranged by frequency of occurrence in all prediction programs. Considering the scores of peptides in the prediction program and their frequency of ranking in the top five, the most likely H-2Kd-, H-2Dd- or H-2Ld-specific binding peptides (two peptides for each) were selected for further evaluation. […]

Pipeline specifications

Software tools NetMHC, NetCTLpan, nHLAPred, ProPred
Application Immune system analysis
Organisms Mus musculus, unidentified adenovirus
Diseases Hemorrhagic Fever, American, Hemorrhagic Fever, Ebola