Dataset features

Specifications


Application: aCGH data analysis
Number of samples: 54
Release date: Jun 30 2012
Last update date: Feb 4 2015
Access: Public
Diseases: Leukemia, Lymphocytic, Chronic, B-Cell
Dataset link Longitudinal Genome Wide Analysis of Chronic Lymphocytic Leukemia Reveals Complex Evolution of Clonal Architecture at Disease Progression and at the Time of Relapse

Experimental Protocol


All patients had genome wide genetic analysis performed by aCGH on at least two sequential tumor samples >6 months apart. For the purposes of this study, we classified samples as; time point 1 (TP1) collected >6 months before starting first-line treatment for disease progression; time point 2 (TP2) consisting of tumor samples at the time of progression requiring treatment; and time point 3 (TP3) consisting of tumor samples collected >6 months after initial treatment but prior to subsequent treatments. Overall, aCGH assay was performed in 54 samples from 22 patients (2 to 4 time points analyzed per patient). Thus, 6 patients were analyzed at TP1 and TP2, 8 patients at TP2 and TP3, 2 patients at TP1 and TP3, and the remaining 6 patients were analyzed at TP1, TP2 and TP3. Keyword : array comparative genomic hybridization

Repositories


GEO

GSE30217

ArrayExpress

E-GEOD-30217

BioProject

PRJNA143983

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Contact


Esteban Braggio