Computational protocol: Eicosapentaenoic and docosahexaenoic acids-rich fish oil supplementation attenuates strength loss and limited joint range of motion after eccentric contractions: a randomized, double-blind, placebo-controlled, parallel-group trial

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Protocol publication

[…] A total of 24 Japanese healthy men (age, 19.5 ± 0.8 years; height, 174.4 ± 6.0 cm; weight, 65.3 ± 7.7 kg; body fat, 13.3 ± 3.1 %) were recruited for this study. They were allergic to fish and resistance training and requested to avoid participation in other clinical trials and interventions such as massage, stretching, strenuous exercise, excessive consumption of food or alcohol, and any supplement or medication during the experimental period. All participants were provided with detailed explanations of the study protocol prior to participation and signed an informed consent form in accordance with the Declaration of Helsinki before being enrolled in this study. This study was approved by the Ethics Committee for Human Experiments at Juntendo University (ID: 26–113) and has been registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR, identifier: UMIN000016149). The estimation was based on the effect size of 1, alpha level of 0.05, and a power (1−b) of 0.80 for the comparison EPA group and PL group following ECC, which showed that at least ten participants were necessary (G*power, version 3.0.10). [...] All analyses were performed using SPSS Statistics software version 20.0 (IBM, Armonk, NY). All variables are expressed as means ± standard deviations (SD). All data were confirmed within the normal distribution by Kolmogorov–Smirnov test. MVC, ROM, upper arm circumference, muscle soreness, and blood samples over time were compared between the PL and EPA groups by a two-way repeated measure analysis of variance (ANOVA). When a significant interaction or time effect was found, Bonferroni’s correction was performed as a post hoc test. A p value of <0.05 was considered to be statistically significant. […]

Pipeline specifications

Software tools G*Power, SPSS
Application Miscellaneous
Organisms Homo sapiens
Chemicals Creatine