Computational protocol: Is the subcallosal medial prefrontal cortex a common site of atrophy in Alzheimer's disease and frontotemporal lobar degeneration?

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Protocol publication

[…] The software program MRIcro (Version 1.37; http://www.mricro.com, http://www.mccauslandcenter.sc.edu/mricro/mricron/) was used for parcellation of the cortex. With this software, an image can be viewed in horizontal, sagittal, and coronal directions simultaneously with a reconstruction of the surface of the brain. Measurements were subsequently performed using the HERMES MultiModality software package (Nuclear Diagnostics, Stockholm, Sweden). Regions of interest were traced manually on contiguous coronal sections. The intracranial volume (ICV) was obtained by using a stereologic point-counting technique comprising manual tracing of the ICV on every fourth slice, following landmarks proposed by Eritaia et al. ().The SMPC was traced in the coronal orientation. The anterior border was defined as the first slice in which the callosal white matter connects the two hemispheres (Figure ) and the posterior border was the last slice in which the inferior part of the corpus callosum could be visualized (Figure ). Between these landmarks all gray matter on the ventromedial surface was included. Intraclass correlation coefficients (ICCs) were calculated to estimate the reliability of measurements. Tracings of other frontal regions were carried out following Suzuki et al. (). For DLPFC we combined the gray matter volume of the superior frontal gyrus with that of the middle frontal gyrus. The reliability of the SMPC measurements was investigated on two occasions and was >0.91 both times. The ICC for other cortical regions has been reported previously (Lindberg et al., ), but in short all ICCs were greater than 0.90. All statistical calculations were performed on normalized volume of measured region, derived by dividing the volume of the region by the ICV. [...] Volumetric data were analyzed by One-Way analysis of variance with a Fisher LSD post-hoc test using Statistica 10 (StatSoft, Inc., 2011). All volumetric data were normalized by ICV by the formula volume of region/ICV. A P value less than 0.05 was considered significant. […]

Pipeline specifications

Software tools MRIcro, MRIcron, Statistica
Applications Miscellaneous, Magnetic resonance imaging
Organisms Homo sapiens
Diseases Adrenal Cortex Diseases, Alzheimer Disease, Dementia, Epidermolysis Bullosa, Junctional, Neurodegenerative Diseases, Frontotemporal Lobar Degeneration, Frontotemporal Dementia