Computational protocol: miR-16 and miR-103 impact 5-HT4 receptor signalling and correlate with symptom profile in irritable bowel syndrome

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Protocol publication

[…] Comparative in silico analyses of miRNA binding sites in the HTR4 gene were performed using the online prediction tools miRWalk,, RegRNA 1.0, miRanda and TargetScan4.2 (www.targetscan.org). Putative miRNA binding sites predicted by at least two different algorithms were taken into account.A summary of all samples and applied experiments is given in the Supplementary (Supplementary Figure ).The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request. […]

Pipeline specifications

Software tools RegRNA, MiRanda, TargetScan
Databases miRWalk
Application Transcription analysis
Organisms Homo sapiens
Diseases Irritable Bowel Syndrome
Chemicals Serotonin