Computational protocol: Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus

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Protocol publication

[…] The associations between SNPs and gout were examined with logistic regression analyses. For the robustness of the statistical test, random re-sampling methods with computer simulation are often applied. In this study, the permutation test was used for random re-sampling in a case-control study with replacement for 1,000,000 times, and the robustness of statistics was confirmed. All the logistic regression analyses and chi-square tests were performed with SPSS v.22.0J (IBM Japan Inc., Tokyo, Japan) and the software R (version 3.1.1) ( We examined the pairwise LD using PLINK v1.07. […]

Pipeline specifications

Software tools SPSS, PLINK
Applications Miscellaneous, GWAS
Organisms Homo sapiens
Diseases Genital Neoplasms, Male, Gout
Chemicals Ethanol, Uric Acid