Computational protocol: Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

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Protocol publication

[…] The protein structure homology models of selected yeast-displayed antibody single-chain variable fragments CK129, CK138, and CK157 have been generated by using protein structure modeling program MODELLER and the three-dimensional structure of a highly homolog synthetic antibody fragment as a template (PDB ID: 2KH2). Protein structures and models were rendered using PyMOL (PyMOL Molecular Graphics System, Version 1.8 Schrödinger, LLC). […]

Pipeline specifications

Software tools MODELLER, PyMOL
Application Protein structure analysis