Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 100
Release date: Jan 16 2013
Last update date: Apr 5 2017
Access: Public
Diseases: Arthritis, Juvenile, Scleroderma, Systemic, Cryopyrin-Associated Periodic Syndromes
Dataset link Microarray-based gene expression profiling in patients with cryopyrin-associated periodic syndromes defines a disease-related signature and IL-1-responsive transcripts.

Experimental Protocol


We collected peripheral blood mononuclear cells from 23 CAPS patients with active disease and from 14 healthy children. Transcripts that passed stringent filtering criteria (p values ≤ false discovery rate 1%) were considered as differentially expressed genes (DEG). A set of DEG was validated by quantitative reverse transcription PCR and functional studies with primary cells from CAPS patients and healthy controls. We used 17 CAPS and 43 non-CAPS patient samples to create a set of gene expression models that differentiates CAPS patients from controls and from patients with other autoinflammatory conditions.

Repositories


GEO

GSE43553

ArrayExpress

E-GEOD-43553

BioProject

PRJNA186687

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Contact


abdel elkahloun