Computational protocol: Structure of a Single-Chain Fv Bound to the 17 N-Terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression

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Protocol publication

[…] The programs Contact, HBplus and Areaimol (Collaborative Computational Project Number 4) were used to analyze the structural and chemical features of the complex, namely, inter-atomic distances, hydrogen bonds and changes in solvent-accessible surface area upon complex formation. The Web server PISA was used to score the biological significance of the various interfaces formed by the protein chains within the crystal . Figures were prepared using the program PyMOL. […]

Pipeline specifications

Software tools HBPLUS, PyMOL
Application Protein sequence analysis
Diseases Huntington Disease