Computational protocol: Central as well as Peripheral Attentional Bottlenecks in Dual-Task Performance Activate Lateral Prefrontal Cortices

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Protocol publication

[…] Data were analyzed using SPM12. First, the origin of the anatomical and functional images was manually set to the anterior commissure and all images were reoriented. To correct for movements, all functional volumes were spatially realigned to the first functional volume, and signal changes due to head motion and magnetic field inhomogeneities were corrected (Realign and Unwarp; Andersson et al., ). Anatomical and functional images were normalized to MNI space using unified segmentation. Finally, the functional data were spatially smoothed using a Gaussian kernel with a FWHM of 8 mm. Normalization and registration success was validated by visual inspection.Both studies employed block-designs, and statistical analysis was based on a voxel-wise least-squares estimation using the general linear model for serially autocorrelated observations (Friston et al., ). Temporal high-pass filters with cut-off frequencies of 1/165 Hz (CB group) and 1/180 Hz (PB group) were applied. Individual contrast maps were calculated for all contrasts of interest (see “Results” Section), and the second-level analysis was based on random-effects one-sample t-tests. Because the data of the CB and PB groups were derived from two different scanning sites, we did not compare them directly, e.g., by using two-sample t-tests. All resulting t-maps were thresholded at p < 0.05 (FWE corrected for multiple comparisons). For display purposes, graphs were thresholded at p < 0.00005 (uncorrected). All stereotaxic coordinates are reported in MNI space. Anatomical locations and Brodmann’s areas (BAs) were preferentially determined using the SPM Anatomy toolbox (Eickhoff et al., ) or alternatively the Automated Anatomical Labeling toolbox (Tzourio-Mazoyer et al., ). […]

Pipeline specifications

Software tools SPM, AAL
Application Magnetic resonance imaging
Organisms Homo sapiens
Diseases Brain Diseases