|Application:||Gene expression microarray analysis|
|Number of samples:||18|
|Release date:||Mar 31 2018|
|Last update date:||Sep 27 2018|
|Diseases:||Lung Diseases, Lung Neoplasms, Neoplasms, Carcinoma, Lewis Lung|
|Dataset link||Expression profile comparison between paired tumor- and normal tissue-associated MSCs from lung carcinoma patients|
MSCs were isolated from paired lung tumor (T-) and normal tissues (N-) from 9 patients diagnosed with lung carcinoma and characterized for surface expression markers and differentiation potential. RNA was extracted at culture passage 5 or 6 from fresh MSCs (frozen in DMSO-FBS10%) to be sure to have pure MSC cell culture representative of the pathophysiological characteristics of the primary samples. Paired N- and T-MSC expression profiles were analyzed using Affymetrix microarrays. We sought to identify differentially expressed genes between N- and T-MSCs to gain insight into the mechanisms whereby the stroma promotes lung cancer metastasis.
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