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edira specifications


Unique identifier OMICS_09009
Name edira
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


  • person_outline Martin Schäfer <>

Publication for edira

edira citations


Integrative analysis of genome wide gene copy number changes and gene expression in non small cell lung cancer

PMCID: 5675410
PMID: 29112949
DOI: 10.1371/journal.pone.0187246

[…] estimates. to assess the correlation between ge and cn, the externally centered correlation coefficient (eccc) was calculated, essentially as described by schäfer et al. [] using the r package ‘edira’ []. for each probe set, eccc considers the equally directed deviations of cn and ge intensities from the median of an external reference group. the hapmap data set [] was used as external […]


An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma

PMCID: 4605796
PMID: 26465158
DOI: 10.1371/journal.pone.0139808

[…] registered as gse47404., our analysis flow in this study is summarized in . to identify differentially expressed genes associated with cnas in escc, we applied gene expression and acgh data to the edira algorithm []. this algorithm is characterized as the bivariate approach with the assessment of the equally directed abnormality of copy number and gene expression. instead of a two-step […]

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edira institution(s)
Collaborative Research Center 475; Department of Statistics, TU Dortmund University, Dortmund, Germany; Department of Biostatistics, Johns Hopkins University, Baltimore, USA; Galenus-G.H. AG, Basel, Switzerland; MLL Munich Leukemia Laboratory, Munich; Department of Medical Informatics and Biomathematics, University of Münster, Münster, Germany
edira funding source(s)
Deutsche Forschungsgemeinschaft (SFB 475, ‘Reduction of Complexity in Multivariate Data Structures’); the European Leukemia Network of Excellence (LSHC-CT-2004); COST action BM0801 Translating genomic and epigenetic studies of MDS and AML (EuGESMA)

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