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Conserves the thermodynamic stability of multiple sequence alignments (MSAs). EDNA (Energy Based Multiple Sequence Alignment) is an extension of the open source MSA program Opal. Finds the correct alignment where a dinucleotide substitution is possible thermodynamically without disrupting the free energy of neighboring interactions. EDNA avoids problems resulting from under-sampling in a set of transcription factor binding sites (TFBSs), which may be particularly valuable when building alignments for non-global regulators.

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EDNA forum

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EDNA classification

EDNA specifications

Unique identifier:
OMICS_00974
Software type:
Package/Module
Restrictions to use:
None
Programming languages:
Java
Stability:
Stable
Name:
Energy Based Multiple Sequence Alignment
Interface:
Command line interface
Operating system:
Unix/Linux
Computer skills:
Advanced
Maintained:
Yes

EDNA distribution

versioning

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No versioning.

EDNA support

Maintainer

  • Dov Stekel <>

Credits

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Publications

Institution(s)

Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK and School of Biosciences, University of Nottingham, Sutton Bonington Campus, Leicestershire, UK

Funding source(s)

Supported by the Darwin Trust of Edinburgh.

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