Dataset features

Specifications


Dataset type: Expression profiling by high throughput sequencing, Other
Number of samples: 42
Release date: Feb 11 2019
Last update date: Feb 16 2019
Access: Public
Dataset link The CDK7 Inhibitor THZ1 Alters RNA Polymerase Dynamics at the 5’ and 3’ Ends of Genes

Experimental Protocol


Kasumi-1 cells were treated with DMSO, 400nM flavopiridol (FVP), 25nM dinaciclib (Dina), 5uM PHA-767491 (PHA), 400nM THZ1 and 5uM palbociclib (Palbo) for 1hr and PROseq and RNAseq were performed to study changes in transcription and gene expression. Kasumi-1 cells were treated with 400nM THZ1 for 0, 15, 30,60 and 120 minutes and PROseq was performed. RNAseq was performed for 0 and 2hr THZ1 treated samples. Two biological replicates were included for each time point.

Repositories


GEO

GSE102243

ENA

SRP114794

BioProject

PRJNA397075

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Contact


Scott Hiebert