Dataset features

Specifications


Dataset type: Methylation profiling by high throughput sequencing
Number of samples: 11
Release date: Feb 19 2019
Last update date: Feb 20 2019
Access: Public
Dataset link SETD2 regulates the maternal epigenome and embryonic development [Bisulfite-seq]

Experimental Protocol


Mouse GO_P7, GO_P10, GO_P14, FGO, MII oocyte, zygote, late 2-cell, 8-cell and ICM from E3.5 blastocyst were obtained and performed STAR ChIP-seq to determine the H3K36me3 distribution. FGO in Dnmt3L KO mice and Setd2 maternal KO mice were collected and conducted STAR ChIP-seq, STEM-seq and RNA-seq to explore the cross talk between histone modifications. STAR ChIP-seq and RNA-seq were performed in Setd2 maternal KO zygote to test if abnormal H3K4me3 and transcription can be inherited in mutant embryo. GO = growing oocyte FGO = full grown oocyte

Repositories


GEO

GSE112833

ENA

SRP137906

BioProject

PRJNA449121

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Contact


Yunlong Xiang