Computational protocol: Alterations in White Matter Evident Before the Onset of Psychosis

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Protocol publication

[…] Images were corrected for head movement, eddy currents, and skull-stripped using FSL (http://www.fmrib.ox.ac.uk/fsl/). The 6 elements of the diffusion tensor were calculated for each voxel using linear regression. FA was calculated and data from all subjects realigned to the bicommissural line of a target image (chosen from the study participants) using an affine followed by nonlinear registration. The nonlinear transformation was then applied to each tensor component, and the warped components were recombined into a single tensor file. In order to allow for the effects of this reorientation, the local tensor orientation was adjusted using the “preservation of principal direction” algorithm implemented within Camino (http://cmic.cs.ucl.ac.uk/camino). Finally, realigned diffusion tensor images of all subjects were used to create a population-specific template to which each subject's images were then (re-)normalized; this final stage of processing was performed with “dti-tk” toolkit (http://www.nitrc.org/projects/dtitk) and is described in more detail below. […]

Pipeline specifications

Software tools Camino, DTI-TK
Application Diffusion magnetic resonance imaging analysis
Organisms Homo sapiens
Diseases Psychoses, Substance-Induced
Chemicals Fluocinolone Acetonide