EFICAz statistics

info info

Citations per year

Number of citations per year for the bioinformatics software tool EFICAz
info

Tool usage distribution map

This map represents all the scientific publications referring to EFICAz per scientific context
info info

Associated diseases

This word cloud represents EFICAz usage per disease context
info

Popular tool citations

chevron_left Function prediction Pairwise structure alignment Protein structure comparison chevron_right
Want to access the full stats & trends on this tool?

Protocols

EFICAz specifications

Information


Unique identifier OMICS_22391
Name EFICAz
Alternative names Enzyme Function Inference by a Combined Approach, EFICAz2, EFICAz2.5
Interface Web user interface
Restrictions to use Academic or non-commercial use
Computer skills Basic
Version 2.5
Maintained No

Maintainer


This tool is not available anymore.

Information


Unique identifier OMICS_22391
Name EFICAz
Alternative names Enzyme Function Inference by a Combined Approach, EFICAz2, EFICAz2.5
Software type Application/Script
Interface Command line interface
Restrictions to use Academic or non-commercial use
Operating system Unix/Linux
Computer skills Advanced
Version 2.5
Maintained No

Download


download.png

Versioning


No version available

Maintainer


This tool is not available anymore.

Publications for Enzyme Function Inference by a Combined Approach

EFICAz citations

 (20)
library_books

Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites: Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149

2018
Front Microbiol
PMCID: 5766836
PMID: 29375494
DOI: 10.3389/fmicb.2017.02528

[…] d in this paper is version PJQD01000000.Predicted protein sequences from the MD1149 genome were processed through automated functional annotation using the PSAT metaserver (Leung et al., ), which ran EFICAz 2.5 (Kumar and Skolnick, ), blastp against the KEGG, MetaCyc, BRENDA, and STRING databases (Caspi et al., ; Chang et al., ; Szklarczyk et al., ; Kanehisa et al., ), and Interproscan (Jones et a […]

library_books

Metagenomic mining for thermostable esterolytic enzymes uncovers a new family of bacterial esterases

2016
Sci Rep
PMCID: 5171882
PMID: 27991516
DOI: 10.1038/srep38886

[…] -A match from the list of lipolytic-related domains, an α/β hydrolase_3 domain (PF07859). Further curation of the sequence included putative EC assignment by exploiting a machine-learning based tool; EFICAZ 2.5 returned a low-confidence (EFICAz_components: CHIEFc_FDR, MTTSI_bin: 2) EC prediction of 3.1.1.x. Furthermore, EstDZ2α showed 23% amino acid sequence identity (e-value 6 × 10−24, query cove […]

library_books

The genome of Onchocerca volvulus, agent of river blindness

2016
Nat Microbiol
PMCID: 5310847
PMID: 27869790
DOI: 10.1038/nmicrobiol.2016.216

[…] .9, ≥5 positive hits100), (2) BLASTP (e-value 1e-10 against SWISSPROT enzymes), (3) PRIAM enzyme rel. Feb-2014 (minimum probability >0.5, profile coverage >70%, check catalytic - TRUE), (4) KAAS, (5) EFICAz and (6) EC assignments from BRENDA. From these assignments, a set of high-confidence predictions was derived as follows from BRENDA, DETECT and reactions identified by both PRIAM and KAAS. Reac […]

library_books

Identification of Multi Functional Enzyme with Multi Label Classifier

2016
PLoS One
PMCID: 4831692
PMID: 27078147
DOI: 10.1371/journal.pone.0153503

[…] 80% accuracy, which is lower than the 93.7% accuracy mentioned in the paper. The public test website http://www.csbio.sjtu.edu.cn/bioinf/EzyPred/EzyPred is free to the public. The second platform is EFICAz2.5[, ]. We obtained 86.4% accuracy with the code obtained from the link http://cssb.biology.gatech.edu/skolnick/webservice/EFICAz2/index.html. This accuracy value is lower than the 92% accuracy […]

library_books

Discovery and Characterization of a Thermostable and Highly Halotolerant GH5 Cellulase from an Icelandic Hot Spring Isolate

2016
PLoS One
PMCID: 4704807
PMID: 26741138
DOI: 10.1371/journal.pone.0146454

[…] 0150.13) and (ii) carbohydrate-binding domain (family 17/28—ID: PF03424.9). Further curation of the sequence included putative EC assignment by exploiting machine-learning based methodologies, namely EFICAz2.5 [] and rpsBLAST against the PRIAM database []. Both software packages predicted an EC number of 3.2.1.4, which is in agreement with the UniProt/Swiss-Prot results. […]

library_books

Application of a hierarchical enzyme classification method reveals the role of gut microbiome in human metabolism

2015
BMC Genomics
PMCID: 4474468
PMID: 26099921
DOI: 10.1186/1471-2164-16-S7-S16

[…] ng the finer levels in the hierarchy, thus offer only limited value to enzyme annotations. Many enzyme prediction methods exhibit a lack of balance between specificity and sensitivity; EzyPred [] and EFICAz2.5 [] offer limited sensitivity for certain enzyme classes and/or EC levels and run extremely slow with high false positive rates. Hence, the existing methods are inadequate for annotation of h […]


Want to access the full list of citations?
EFICAz institution(s)
Center for Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, GA, USA
EFICAz funding source(s)
Supported in part by grant no. GM-48835 of the Division of General Medical Sciences of the National Institutes of Health.

EFICAz reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review EFICAz