ENDEAVOUR statistics

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Protocols

ENDEAVOUR specifications

Information


Unique identifier OMICS_06539
Name ENDEAVOUR
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Taxon


  • Invertebrates
    • Caenorhabditis elegans
    • Drosophila melanogaster
  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus
  • Vertebrates
    • Danio rerio

Maintainer


  • person_outline Yves Moreau

Additional information


https://endeavour.esat.kuleuven.be/Help.aspx

Publications for ENDEAVOUR

ENDEAVOUR citations

 (48)
library_books

Characterization of a new B ALL cell line with constitutional defect of the Notch signaling pathway

2018
Oncotarget
PMCID: 5915076
PMID: 29719609
DOI: 10.18632/oncotarget.24836

[…] OTCH3, EPHA2, NCOR1 and PIK3C2B (Table ). To support the results obtained and identify further putative pathogenetic variants for B-ALL, we turned to disease-network analysis. We used two algorithms: Endeavour [] and ToppGene []. The results of gene prioritization are shown in Table . Interestingly, we observed a similar pattern of mutation events between initial patient cells and the VR-ALL line […]

library_books

A defect in the inner kinetochore protein CENPT causes a new syndrome of severe growth failure

2017
PLoS One
PMCID: 5724856
PMID: 29228025
DOI: 10.1371/journal.pone.0189324

[…] eous Turkish family with one unaffected and two affected children () revealed 5 shared regions of homozygosity, which were larger than 1Mb in size. Candidate gene prioritization using ToppGene [] and Endeavour [] resulted a total of 67 genes within these regions of homozygosity. Two candidate genes (LIG4 (MIM:*601837); CENPT) were identified following manual annotation and filtration by biological […]

library_books

A Strategy for Identifying Quantitative Trait Genes Using Gene Expression Analysis and Causal Analysis

2017
Genes
PMCID: 5748665
PMID: 29186889
DOI: 10.3390/genes8120347

[…] strains [] are available.Second, bioinformatics analyses using the information about the nsSNPs detected and genes located in the QTL intervals were performed with three web-based software programs, Endeavour, SIFT and PolyPhen-2, which generate a prioritized list of positional and functional candidate genes. Endeavour prioritizes candidate genes on the basis of similarity to training genes that […]

library_books

Dysfunction of Myosin Light‐Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically‐Engineered Rats

2017
PMCID: 5721782
PMID: 29080865
DOI: 10.1161/JAHA.117.007030

[…] ded a maximal logarithm of the odds score of 5.3 (Figure A). Haplotype analysis showed a ≈6 Mbp (or ≈5 cM) region exclusively shared by patients.Based on bioinformatic analysis, both GeneWanderer and Endeavour ranked MYL4 in the top 2 genes in terms of its functional relationship to SCN5A and GJA5 (listed in Tables and ). Importantly, the identified missense mutation c. 31G>A in MYL4 changed the […]

call_split

Whole exome sequencing as a diagnostic tool for patients with ciliopathy like phenotypes

2017
PLoS One
PMCID: 5553726
PMID: 28800606
DOI: 10.1371/journal.pone.0183081
call_split See protocol

[…] utation Taster [] and the likelihood ratio test (LRT) []). Once potentially pathogenic variants were selected, COBALT [] was used to analyse protein residue conservation across species. Additionally, Endeavour [] and ToppGene Suite [] prioritisation tools were used to rank the final list of variants, with a training set of 51 known ciliary genes (). For those top genes, STRING [] and GENEMANIA [] […]

library_books

brain coX: investigating and visualising gene co expression in seven human brain transcriptomic datasets

2017
Genome Med
PMCID: 5465565
PMID: 28595657
DOI: 10.1186/s13073-017-0444-y

[…] ine Mendelian Inhertiance in Man (OMIM) database [], as well as gene expression data from healthy individuals [, ]. Popular examples of computational methods offering in silico prioritisation include Endeavour [] and ToppGene []. One of the most frequently employed visualisation tools for gene networks is String [].Both in silico prioritisation and gene network visualisation tools have been succes […]

Citations

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ENDEAVOUR institution(s)
Department of Electrical Engineering ESAT-SCD, Katholieke Universiteit Leuven, Belgium; Human Genome Laboratory, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium; Department of Human Genetics, Katholieke Universiteit Leuven School of Medicine, VIB, Leuven, Belgium; Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium
ENDEAVOUR funding source(s)
Supported by the Research Council KUL (GOA AMBioRICS, CoE EF/05/007 SymBioSys, PROMETA, several PhD/postdoc & fellow grants), FWO [PhD/postdoc grants, projects G.0241.04 (Functional Genomics), G.0499.04 (Statistics), G.0232.05 (Cardiovascular), G.0318.05 (subfunctionalization), G.0553.06 (VitamineD), G.0302.07 (SVM/Kernel), research communities (ICCoS, ANMMM, MLDM)], IWT (PhD Grants, GBOU-McKnow-E (Knowledge management algorithms), GBOU-ANA (biosensors), TAD-BioScopeIT, Silicos; SBO-BioFrame, SBO-MoKa, TBM Endometriosis), the Belgian Federal Science Policy Office [IUAP P6/25 (BioMaGNet, Bioinformatics and Modeling: from Genomes to Networks, 2007-2011), and the EU-RTD (ERNSI: European Research Network on System Identification; FP6-NoE Biopattern; FP6-IP e-Tumours, FP6- MC-EST Bioptrain, FP6-STREP Strokemap)].

ENDEAVOUR review

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Anonymous user #32503

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Web
Easy to use, but the disease input could be expanded for better disease-gene association coverage.