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EnigmaVis specifications


Unique identifier OMICS_19297
Name EnigmaVis
Interface Web user interface
Restrictions to use None
Input data A GWAS data.
Input format CSV
Programming languages Javascript
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Arthur Toga

Publication for EnigmaVis

EnigmaVis citations


Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

Nat Commun
PMCID: 5826945
PMID: 29483533
DOI: 10.1038/s41467-018-03247-3

[…] odel was used to perform the meta-analysis. The associations between eSNPs of ALMS1, GLT8D1, and CSNK2B, and hippocampal structure were extracted from the ENIGMA website (https://www.enigma-brain.org/enigmavis/visualizer/visualizer). More detailed information about the ENIGMA (including sample description, MRI collection, genotyping, quality control, and statistical analyses can be found in the or […]


Genome wide association study of paliperidone efficacy

Pharmacogenet Genomics
PMCID: 5152628
PMID: 27846195
DOI: 10.1097/FPC.0000000000000250

[…] with treatment response even when controlling for baseline symptom severity and duration of illness . The relationships between rs9323656 and other brain regions are unknown, except those examined in EnigmaVis and ENIGMA2 . Given the results with risperidone, it is noteworthy that the ADCK1 variant influences both ICV and paliperidone response, especially as paliperidone (9-hydroxyrisperidone) is […]


Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease

BMC Genomics
PMCID: 4192369
PMID: 25280473
DOI: 10.1186/1471-2164-15-850

[…] ocampus volume from healthy subjects and patients was generated for GWAS meta-analyses by the Enhancing Neuro Imaging Genetics Through Meta-Analysis (ENIGMA) network [, , ] and can be visualised with ENIGMAvis []. Association analyses used multiple linear regression with hippocampus volume as a dependent variable and the additive dosage of each SNP as an independent variable, controlling for covar […]


Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Mol Psychiatry
PMCID: 4051592
PMID: 24514566
DOI: 10.1038/mp.2013.197

[…] 171755 with significant decrease of brain volume of 3080 mm3 (β=−3080, P=0.0457) per risk allele. We have replicated this finding in the subsample of healthy individuals (n=5775) of ENIGMA, using the EnigmaVis tool, confirming the negative effects of the risk allele on brain volume (decrease of 5945.91 mm3 per risk allele: β=−5945.91, P=0.00327; ). Altogether, these results further support a role […]


A Genome Wide Association Study Suggests Novel Loci Associated with a Schizophrenia Related Brain Based Phenotype

PLoS One
PMCID: 3689744
PMID: 23805179
DOI: 10.1371/journal.pone.0064872

[…] checked for association signals with bilateral hippocampal volume for the aforementioned SNPs (if available) and all other available intragenic SNPs in a window of +/−100 kb of our top SNPs (I) using EnigmaVis, an online interactive visualization tool of genome-wide association signals of the ENIGMA study , and (II) estimating similar linear regression models as described above using the IMAGEN da […]

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EnigmaVis institution(s)
Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Quantitative Genetics, Queensland Institute of Medical Research, Brisbane, QLD, Australia
EnigmaVis funding source(s)
Supported by the National Institutes of Health (NIH) and the National Center for Research Resources (NCRR) grant P41 RR013642, the NSF GRFP grant DGE-0707424, an Australian Research Council Future Fellowship FT110100548, the NIH Postdoctoral Training Grant in Neurobehavioral Genetics, and NIH grants U01 AG024904, EB008432, P41 RR013642, HD050735, AG036535, EB008281.

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