Epigenomics is the large-scale study of epigenetic modifications, reversible and heritable phenotypic changes of DNA or histones in a cell that affect gene expression without altering the DNA sequence. Epigenetic modifications can be grouped into three main categories, DNA methylation, histone modifications and nucleosome positioning. Bisulfite sequencing (BS-seq) is the leading technology in epigenomics. Epigenetic modifications are central in human diseases, including cancer.
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