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ESpritz specifications


Unique identifier OMICS_03632
Name ESpritz
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for ESpritz

ESpritz citations


Functional and structural characterization of osteocytic MLO Y4 cell proteins encoded by genes differentially expressed in response to mechanical signals in vitro

Sci Rep
PMCID: 5928037
PMID: 29712973
DOI: 10.1038/s41598-018-25113-4

[…] mouse. The degree of interconnectedness was quantified by its number of PPIs. We annotated putative intrinsic disorder using a majority-vote based consensus of five predictors: three versions of the Espritz method and two versions of the IUPred method; These methods are characterized by complementary designs and were empirically demonstrated to offer strong predictive quality for the prediction o […]


Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder Enriched Interactions

Int J Mol Sci
PMCID: 5751360
PMID: 29257115
DOI: 10.3390/ijms18122761

[…] ly annotated the intrinsic disorder based on the presence of disordered regions, DPB regions, and MoRF regions. We predicted intrinsic disorder using a consensus of two popular methods: IUPred [] and ESpritz []. We selected these methods based on their favorable predictive quality [,,], the runtime which is sufficiently short to process the 15 thousand proteins, and complementary designs. To the l […]


Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway

PLoS Comput Biol
PMCID: 5746249
PMID: 29240760
DOI: 10.1371/journal.pcbi.1005885

[…] ering criteria, we gathered various predicted features of the PSSM-identified peptides. The methods we used included PFAM annotations [], average disorder prediction scores (using IUPred, PONDR VSL2, Espritz and DISOPRED3) [–], average score to be part of disordered binding regions (using ANCHOR, MORF-CHIBI and DISOPRED3-BR) [–], and secondary structure prediction scores using PSIPRED []. At the p […]


Disulfide driven folding for a conditionally disordered protein

Sci Rep
PMCID: 5717278
PMID: 29208936
DOI: 10.1038/s41598-017-17259-4

[…] Intrinsic disorder in hCox17 was predicted using the web-based algorithms FoldIndex, IUPRED, ESpritz, PONDR-FIT and RONN with default settings. An 11-residue sliding window was used in all cases. […]


A Comprehensive Survey of the Roles of Highly Disordered Proteins in Type 2 Diabetes

Int J Mol Sci
PMCID: 5666700
PMID: 28934129
DOI: 10.3390/ijms18102010
call_split See protocol

[…] et database [] (available online:, which is a community database for the pre-computed disorder predictions. D2P2 combines outputs of PONDR® VLXT, IUPred, PONDR® VSL2B [,], PrDOS [], ESpritz [], and PV2 [] to show disorder predisposition of a query protein. It is further enhanced by the information on the curated sites of various posttranslational modifications and on the location […]


Potential Roles of Intrinsic Disorder in Maternal Effect Proteins Involved in the Maintenance of DNA Methylation

Int J Mol Sci
PMCID: 5618547
PMID: 28869544
DOI: 10.3390/ijms18091898

[…] disorder information for target proteins using the MobiDB database ( [,], which aggregates the outputs from 10 disorder predictors, such as DisEMBL in two of its flavours, ESpritz in its three flavours, GlobPlot, IUPred in its two flavours, JRONN and VSL2b. MobiDB also has additional annotations related to protein structure and interaction derived from UniProt [], Pfam […]


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ESpritz institution(s)
Department of Biology, University of Padua, Padova, Italy

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