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euHCVdb specifications


Unique identifier OMICS_12691
Name euHCVdb
Alternative name European Hepatitis C Virus database
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Version 122.0
Maintained Yes


  • Viruses
    • Hepatitis C virus genotype 2
    • Hepatitis C virus genotype 3
    • Hepatitis C virus genotype 4


  • person_outline Christophe Combet

Publications for European Hepatitis C Virus database

euHCVdb citations


Natural HCV variants with increased replicative fitness due to NS3 helicase mutations in the C terminal helix α18

Sci Rep
PMCID: 4726148
PMID: 26787124
DOI: 10.1038/srep19526

[…] From the European HCV database (, we retrieved 218, 359, 46 and 29 worldwide NS3 sequences of strains from genotype 1a, 1b, 2 and 3 respectively. Sequences likely represent true variants present within the d […]


Aminoterminal Amphipathic α Helix AH1 of Hepatitis C Virus Nonstructural Protein 4B Possesses a Dual Role in RNA Replication and Virus Production

PLoS Pathog
PMCID: 4231108
PMID: 25392992
DOI: 10.1371/journal.ppat.1004501
call_split See protocol

[…] Sequence analyses were performed using the web-based tools available at the European HCV Database ( and the Network Protein Sequence Analysis (NPSA) website of the Institut de Biologie et Chimie des Protéines (IBCP) ( . Multiple sequence alignment and anal […]


Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource

PMCID: 4063340
PMID: 24115039
DOI: 10.1002/hep.26744

[…] Website at and will be updated regularly by the authors with information shared across existing HCV databases (;, typing tools, and other resources (e.g.,;; […]


Phylogeography, Risk Factors and Genetic History of Hepatitis C Virus in Gabon, Central Africa

PLoS One
PMCID: 3411564
PMID: 22870274
DOI: 10.1371/journal.pone.0042002
call_split See protocol

[…] sis, NS5B nucleotide sequences were aligned initially by CLUSTAL_X 1.81 and subsequently adjusted by hand. The sequences were compared with reference sequences from the European HCV database ( and the Los Alamos database ( Phylogenetic trees were estimated and assessed by the bootstrapping and neighbor-joining methods under the Kimura two-para […]


Structural and Functional Studies of Nonstructural Protein 2 of the Hepatitis C Virus Reveal Its Key Role as Organizer of Virion Assembly

PLoS Pathog
PMCID: 3002993
PMID: 21187906
DOI: 10.1371/journal.ppat.1001233

[…] Sequence analyses were performed by using Network Protein Sequence Analysis (NPSA) ( ) and European HCV Database ( ). Multiple-sequence alignments were performed with CLUSTAL W , by using the default options. Protein secondary structures were deduced from a large set of prediction methods available […]


A Novel Diagnostic Target in the Hepatitis C Virus Genome

PLoS Med
PMCID: 2637920
PMID: 19209955
DOI: 10.1371/journal.pmed.1000031
call_split See protocol

[…] were analyzed using the Lasergene software package (DNAStar). All database work was performed online on Los Alamos National Laboratory (LANL) ( and euHCV ( domains. […]


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euHCVdb institution(s)
Institut de Biologie et Chimie des Protéines (UMR5086), CNRS, University of Lyon 1 IFR 128 BioSciences, Lyon, France; Swiss Institute of Bioinformatics, Geneva, Switzerland; Department for Molecular Virology, University of Heidelberg, Heidelberg, Germany; Institute for Immunology, University of Munich, Munich, Germany; Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland; Department of Virology, INSERM U635, Henri Mondor Hospital, University of Paris XII, Creteil, France; Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; INSERM U271, Lyon, France

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