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Considering that more than 90% of the human multi-exon genes have been found to undergo alternative splicing (AS), exon-skipping could be one of the most important ways to steer transcriptional regulation. RNA-seq enables better characterization and quantification of individual transcriptomes because it can detect both gene expression and alternative splicing AS. Exon-skipping is the most common AS mechanism known in mammals, and is a major contributor to protein diversity in mammals. Exon-skipping results in the loss of an exon in the alternatively spliced mRNA.
Source: (Wang et al., 2015) A survey of computational methods in transcriptome-wide alternative splicing analysis. Biomol Concepts.