eXtasy protocols

View eXtasy computational protocol

eXtasy statistics

To access cutting-edge analytics on consensus tools, life science contexts and associated fields, you will need to subscribe to our premium service.

Subscribe
info

Citations per year

Citations chart
info

Popular tool citations

chevron_left SNP/SNV annotation Variant prioritization chevron_right
Popular tools chart
info

Tool usage distribution map

Tool usage distribution map
info

Associated diseases

Associated diseases

eXtasy specifications

Information


Unique identifier OMICS_00150
Name eXtasy
Software type Pipeline/Workflow
Interface Command line interface
Restrictions to use None
Input format VCF
Operating system Unix/Linux
Computer skills Advanced
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Versioning


Add your version

Information


Unique identifier OMICS_00150
Name eXtasy
Interface Web user interface
Restrictions to use None
Input format VCF
Computer skills Basic
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Publication for eXtasy

eXtasy in pipelines

 (2)
2015
PMCID: 4916229
PMID: 26562225
DOI: 10.1038/gim.2015.137

[…] based on patient phenotype similarity to hpo terms associated with omim disease, and, as we have also observed, this comparison to known human phenotypes is frequently all that is necessary. extasy also incorporates multiple lines of evidence, including clinical phenotypes to predict the deleteriousness of nonsynonymous mutations. phevor compares patients and diseases by using […]

2014
PMCID: 4266634
PMID: 25506935
DOI: 10.1371/journal.pone.0114903

[…] data and prioritization of genomic variants (reviewed in –). these include, but not limited to genemania , string , , toppgene , endeavour widely used by the scientific community. the extasy platform developed by sifrim et al. prioritizes mutations for follow-up validation studies by integrating variant-impact and haploinsufficiency predictions with phenotype-specific […]


To access a full list of citations, you will need to upgrade to our premium service.

eXtasy in publications

 (9)
PMCID: 5647373
PMID: 29044180
DOI: 10.1038/s41598-017-13841-y

[…] genes have no known phenotype associations a random-walk-with-restart algorithm scores proximity to other genes in protein-protein association networks which are implicated in patient phenotypes., extasy employs genomic data fusion to quantify the deleteriousness of nonsynonymous variants which are prioritised dependent on disease phenotypes. extasy evaluates patient data against ten measures […]

PMCID: 5312133
PMID: 28265197
DOI: 10.1098/rspa.2016.0730

[…] by a grant financed by the netherlands organisation for scientific research (nwo), as part of research programme no. 613.001.009. b.l. was supported by grant no. ep/k039512/1, grant no. si2-che: extasy (extensible tools for advanced sampling and analysis) from the engineering and physical sciences research council (uk) and a faculty fellowship from the alan turing institute (ati)., […]

PMCID: 4893190
PMID: 27279779
DOI: 10.1098/rspa.2016.0138

[…] the authors in the lammps software package (http://www.lammps.sandia.gov). moreover, the g-baoab scheme is also currently being implemented in the molecular integrator software tools package of the extasy project (http://www.extasy-project.org). using mist, the g-baoab algorithm will be available in conjunction with amber (http://www.ambermd.org) and gromacs (http://www.gromacs.org) (with […]

PMCID: 4736244
PMID: 26838676
DOI: 10.1186/s13073-016-0261-8

[…] placing causal variants in the top 1 % of filtered candidates across the 47 cohort cases with reported molecular diagnoses of exome variants in omim morbidmap genes. our tool outperformed phen-gen, extasy, phenix, phive, and hiphive in the prioritization of these clinically reported variants., our integrative paradigm can improve efficiency and, potentially, the quality of genomic medicine […]

PMCID: 4916229
PMID: 26562225
DOI: 10.1038/gim.2015.137

[…] based on patient phenotype similarity to hpo terms associated with omim disease, and, as we have also observed, this comparison to known human phenotypes is frequently all that is necessary. extasy also incorporates multiple lines of evidence, including clinical phenotypes to predict the deleteriousness of nonsynonymous mutations. phevor compares patients and diseases by using […]


To access a full list of publications, you will need to upgrade to our premium service.

eXtasy institution(s)
Department of Electrical Engineering, STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium; iMinds Future Health Department, Leuven, Belgium; Laboratory of Molecular Cytogenetics and Genome Research, KU Leuven, Leuven, Belgium

eXtasy reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review eXtasy