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Tests for differences in minor allele frequency between groups and is based on an extra-binomial variation model for pooled sequencing data. extraBinomial can analyse both rare and common variants with lower or more variable pool depths compared to the other methods.

Software type:
Package
Interface:
Command line interface
Restrictions to use:
None
Operating system:
Unix/Linux, Mac OS, Windows
Programming languages:
R
License:
GNU General Public License version 2.0
Computer skills:
Advanced
Version:
extraBinomial version 2.1
Stability:
Stable
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Links

Maintainer

  • Xin Yang <xin.yang at cimr.cam.ac.uk>

Institution(s)

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke’s Hospital, Cambridge CB2 0XY, UK

  • (Yang et al., 2012) Extra-binomial variation approach for analysis of pooled DNA sequencing data. Bioinformatics.
    PMID: 22976083

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