Protein extracellular matrix databases | Sequence data analysis
Tissue-specific extracellular matrices (ECMs) are crucial for normal development and tissue function, and mutations in ECM genes result in a wide range of serious inherited connective tissue disorders.
Provides, in addition to the methods and datasets available in our publications, protocols and resources relevant to research on extracellular matrix (ECM) proteins. In addition, the Matrisome Project hosts a newly developed database MatrisomeDB that compiles in silico and experimental data on matrisome genes and proteins. The aim of this website is to facilitate the use of our protocols by other scientists and to allow their widespread use in future studies.
Provides a registry for clinicians, genetic counselors, and researchers about dystrophic epidermolysis bullosa DEB patients and their associated COL7A1 mutations. The international dystrophic epidermolysis bullosa patient registry also collects data about the genotypes (i.e., the combinations of mutations in RDEB), patients, and clinical and molecular phenotypes in which they are involved. Lists contains all the phenotypes ever found in combination with a certain genotype including the reported exceptions to that most likely outcome.
A freely available database integrating collagen biological and physicochemical properties with known variants. A Web-based, interactive, graphical user interface displays the data as annotations on the collagen protein sequences. COLdb is a comprehensive integration of disparate functional information on the three major fibrillar collagens.
Covers interactions established by extracellular proteins and polysaccharides. MatrixDB contains protein-protein interactions (PPIs) and also protein-glycosaminoglycan interactions. It can be employed to construct interaction networks of extracellular proteins, glycosaminoglycans, proteoglycans, basement membrane or physiological process. This database offers about 1 000 interactions supported by over 1 200 experiments, which have been manually curated.
Permits users to collect comprehensive information concerning a non-collagenous family of extracellular matrix (ECM) proteins, the laminins (LMs). Laminin Database can also assimilate data from several publications to acquire a more comprehensive knowledge of LMs in health and disease. This database is able to search datasets to explore biological aspects of LM in neuromuscular and neurodegenerative disorders.