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F-SNP specifications


Unique identifier OMICS_21039
Name F-SNP
Alternative name The Functional Single Nucleotide Polymorphism database
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Version 1.0
Maintained No


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Publication for The Functional Single Nucleotide Polymorphism database

F-SNP citations


NF kB2 Genetic Variations are Significantly Associated with Non Small Cell Lung Cancer Risk and Overall Survival

Sci Rep
PMCID: 5869671
PMID: 29588475
DOI: 10.1038/s41598-018-23324-3

[…] ng sites in the genomic region of rs12769316. The possible functional role of rs12769316 in the transcriptional regulation of NF-kB2 gene was also predicted from the internet-based bioinformatic tool F-SNP. The second polymorphism (rs7897947) was not related to NF-kB2 protein and mRNA expression although was related to other aspects of NSCLC as is discussed below. It is located on the 8th intron o […]


NOS2 polymorphisms in prediction of benefit from first line chemotherapy in metastatic colorectal cancer patients

PLoS One
PMCID: 5844536
PMID: 29522543
DOI: 10.1371/journal.pone.0193640

[…] iption or protein expression. Functional significance was predicted based on information provided by the National Institute of Environmental Health Science SNP Function Prediction, Queen’s University F-SNP, and the location of the SNP in the protein-coding region of the gene (http://snpinfo.niehs.nih.gov/snpinfo/snptag.htm).Genomic DNA was extracted from peripheral whole blood in TRIBE and MOMA tr […]


Genetic determinants of sporadic breast cancer in Sri Lankan women

BMC Cancer
PMCID: 5809862
PMID: 29433565
DOI: 10.1186/s12885-018-4112-4

[…] P database; http://www.ncbi.nlm.nih.gov/SNP/), presence within an evolutionary conserved region (MutationTaster; http://www.mutationtaster.org/), and putative functional significance of the variants (F-SNP; http://compbio.cs.queensu.ca/F-SNP/). Altogether, a total of 58 SNPs from 36 breast cancer related candidate genes were selected for genotyping (Additional file : Table S1). […]


Low rates of hybridization between European wildcats and domestic cats in a human‐dominated landscape

Ecol Evol
PMCID: 5817136
PMID: 29468044
DOI: 10.1002/ece3.3650

[…] tral analysis) resulted in 80% wildcats and 20% domestic cats in the western group (Figure e), and in 75% wildcats, 25% domestic cats, one F2 and one backcross to wildcat in the central group (Figure f).SNP‐based NewHybrids analyses were consistent across all prior combinations. All individuals (n = 536) resulted in assignments of mean q (i) values of .99 (Figure c). In total, 401 individuals were […]


ADAR1 polymorphisms are related to severity of liver fibrosis in HIV/HCV coinfected patients

Sci Rep
PMCID: 5635123
PMID: 29018269
DOI: 10.1038/s41598-017-12885-4

[…] w=FDR) that calculate the False Discovery Rate (FDR).We also performed an in silico analysis, for evaluating the possible functional implication of each polymorphism, by using different web-tools: a) F-SNP (http://compbio.cs.queensu.ca/F-SNP/) that provides information about the functional effects of SNPs obtained from 16 bioinformatics tools and databases b) Ensembl’s Variant Effect Predictor (VE […]


Cyclin dependent Kinase 5: Novel role of gene variants identified in ADHD

Sci Rep
PMCID: 5533779
PMID: 28754891
DOI: 10.1038/s41598-017-06852-2

[…] Online program F-SNP (compbio.cs.queensu.ca/F-SNP) was used to analyze functional roles of the selected variants. NCBI-CCDS was used to identify functional regions of CDK5. Peripheral blood leukocytes were processed […]

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F-SNP institution(s)
Computational Biology and Machine Learning Lab, School of Computing, Queen’s University, Kingston, ON, Canada
F-SNP funding source(s)
Supported by HS’s NSERC Discovery Grant 298292-04 and CFI New Opportunities Award 10437, and by PL’s Ontario Graduate Scholarship and Duncan & Urlla Carmichael Graduate Fellowship.

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